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Adaptation to hypobaric hypoxia involves GABAA receptors in the pons

机译:对低压缺氧的适应涉及脑桥中的GABAA受体

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The pons, a brain stem region, contains nuclei that participate in the expression of PHFD and LTF. We previously demonstrated that cells in the ventrolateral (vl) pons mediate PHFD. Disrupting activity in this region blocked PHFD without affecting the respiratory response during acute hypoxia (9, 20). Furthermore, stimulating the A5 neuronal population increased splanchnic sympathetic nerve discharge (17). Cells in the ventromedial pons (caudal raphe) project to sympathore-spiratory motor nuclei and mediate LTF (25, 26, 37). The contribution of these pontine nuclei to the adaptation to chronic hypobaric hypoxia (CHH) has not been investigated.
机译:桥(脑干区域)包含参与PHFD和LTF表达的细胞核。我们以前证明腹侧(vl)桥中的细胞介导PHFD。该区域的破坏性活动阻止了PHFD,而没有影响急性缺氧时的呼吸反应(9,20)。此外,刺激A5神经元种群会增加内脏交感神经放电(17)。腹侧脑桥(尾缝)中的细胞投射到交感呼吸运动核并介导LTF(25、26、37)。这些桥脑核对慢性低压缺氧(CHH)适应的贡献尚未进行调查。

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