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首页> 外文期刊>American Journal of Physiology >Intraportally delivered GLP~(-1), in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization
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Intraportally delivered GLP~(-1), in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization

机译：在存在通过外周葡萄糖输注引起的高血糖的情况下，经口递送的GLP〜（-1）不会改变全身葡萄糖的利用

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First published December 4, 2007; doi:10.1152/ajpendo.00642.2007.-After a meal, glucagon-like pep-tide~(-1) (GLP~(-1)) and glucose levels are significantly greater in the hepatic portal vein than in the artery. We have previously reported that, in the presence of intraportal glucose delivery, a physiological increase of GLP~(-1) in the hepatic portal vein increases nonhepatic glucose uptake via a mechanism independent of changes in pancreatic hormone secretion. The arm of the present study was to determine whether intraportal glucose delivery is required to observe this effect. Experiments consisted of a 40-min basal period, followed by a 240-min experimental period, during which conscious 42-h fasted dogs received glucose peripherally to maintain arterial plasma glucose levels at ~(-1)60 mg/dl. In addition, either saline (n = 6) or GLP~(-1) (1 pmol-kg~(-1)-mm~(-1); GLP~(-1), n = 6) was administered intraportally during the experimental period. As in the previous study, the presence of GLP~(-1) did notalter pancreatic hormone levels; however, in the present study, intraportal GLP~(-1) infusion did not result in an increase in whole body glucose utilization. This is despite the fact that arterial and hepatic portal vein GLP~(-1) levels were maintained at the same level as the previous study. Therefore, a physiological elevation of GLP~(-1) in the hepatic portal vein does not increase whole body glucose uptake when hyperglycemia is induced by peripheral glucose infusion. This indicates that a physiological increase in GLP~(-1) augments glucose utilization only when GLP~(-1) and glucose gradients conditions mimic the postprandial state.
机译：首次发布于2007年12月4日; doi：10.1152 / ajpendo.00642.2007。-饭后，肝门静脉中的胰高血糖素样pep-tide〜（-1）（GLP〜（-1））和葡萄糖水平显着高于动脉。我们以前曾报道过，在存在门静脉内葡萄糖递送的情况下，肝门静脉中GLP〜（-1）的生理增加是通过独立于胰腺激素分泌变化的机制来增加非肝葡萄糖摄取。本研究的目的是确定是否需要通过门静脉内葡萄糖递送来观察这种作用。实验包括40分钟的基础期，然后是240分钟的实验期，在此期间，有意识的42小时禁食的狗外周接受葡萄糖以维持动脉血浆葡萄糖水平在〜（-1）60 mg / dl。此外，在手术期间经腔内施用生理盐水（n = 6）或GLP〜（-1）（1 pmol-kg〜（-1）-mm〜（-1）; GLP〜（-1），n = 6）。实验期。与以前的研究一样，GLP〜（-1）的存在并不能改变胰腺激素水平。然而，在本研究中，门内GLP〜（-1）输注并未导致全身葡萄糖利用率的增加。尽管存在这样的事实，即动脉和肝门静脉GLP〜（-1）的水平维持在与先前研究相同的水平。因此，当外周葡萄糖输注引起高血糖时，肝门静脉中GLP〜（-1）的生理升高不会增加全身葡萄糖摄取。这表明，仅当GLP _（-1）和葡萄糖梯度条件模拟餐后状态时，GLP _（-1）的生理增加才会增加葡萄糖利用率。

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