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首页> 外文期刊>American Journal of Physiology >Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
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Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice

机译：小鼠胰岛素敏感性和抵抗性替代指标与高胰岛素正常血糖钳夹估计值的比较

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First published November 14,2007; doi:10.1152/ajpendo.00676.2007.-Insulin resistance contributes to the pathophysiology of diabetes, obesity, and their cardiovascular complications. Mouse models of these human diseases are useful for gaining insight into pathophysiological mechanisms. The reference standard for measuring insulin sensitivity in both humans and animals is the euglycemic glucose clamp. Many studies have compared surrogate indexes of insulin sensitivity and resistance with glucose clamp estimates in humans. However, regulation of metabolic physiology in humans and rodents differs and comparisons between surrogate indexes and the glucose clamp have not been directly evaluated in rodents previously. Therefore, in the present study, we compared glucose clamp-derived measures of insulin sensitivity (GIR and SIciamp) with surrogate indexes, including quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment (HOMA), 1/HOMA, log(HOMA), and 1/fasting insulin, using data from 87 mice with a wide range of insulin sensitivities. We evaluated simple linear correlations and performed calibration model analyses to evaluate the predictive accuracy of each surrogate. All surrogate indexes tested were modestly correlated with both GIR and SI_(Clamp). However, a stronger correlation between body weight 0per se and both GIR and SI_(Clamp) was noted. Calibration analyses of surrogate indexes adjusted for body weight demonstrated improved predictive accuracy for GIR [e.g., R = 0.68, for QUICKI and log(HOMA)]. We conclude that linear correlations of surrogate indexes with clamp data and predictive accuracy of surrogate indexes in mice are not as substantial as in humans. This may reflect intrinsic differences between human and rodent physiology as well as increased technical difficulties in performing glucose clamps in mice.
机译：首次发布时间：2007年11月14日; doi：10.1152 / ajpendo.00676.2007.-胰岛素抵抗有助于糖尿病，肥胖症及其心血管并发症的病理生理。这些人类疾病的小鼠模型可用于深入了解病理生理机制。用于测量人和动物胰岛素敏感性的参考标准是正常血糖钳位。许多研究已将人体对胰岛素敏感性和耐药性的替代指标与葡萄糖钳制评估进行了比较。然而，人类和啮齿动物的代谢生理调节不同，替代指标和葡萄糖钳位之间的比较以前尚未在啮齿动物中直接评估。因此，在本研究中，我们将葡萄糖钳制衍生的胰岛素敏感性测量值（GIR和SIciamp）与替代指标进行了比较，这些替代指标包括定量胰岛素敏感性检查指数（QUICKI），体内稳态模型评估（HOMA），1 / HOMA，log（使用来自87个具有广泛胰岛素敏感性的小鼠的数据和1 /空腹胰岛素。我们评估了简单的线性相关性，并进行了校准模型分析，以评估每个替代指标的预测准确性。所有测试的替代指标均与GIR和SI_（Clamp）适度相关。但是，注意到体重0本身与GIR和SI_（Clamp）两者之间具有更强的相关性。根据体重调整的替代指标的校准分析显示，GIR的预测准确性有所提高[例如，QUICKI和log（HOMA）的R = 0.68]。我们得出的结论是，替代指标与钳位数据的线性相关性和替代指标在小鼠中的预测准确性并不像人类那样重要。这可能反映出人类和啮齿动物生理之间的内在差异，以及在小鼠中进行葡萄糖钳夹的技术难度增加。

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