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首页> 外文期刊>American Journal of Physiology >Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats
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Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats

机译：特定促肾上腺皮质激素释放因子受体亚型的拮抗作用选择性地改变了受约束大鼠的体重减轻

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Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats. Am J Physiol Regul Integr Comp Physiol 295: R1762-R1773, 2008. First published October 15, 2008; doi:10.1152/ajpregu.00196.2008.-Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, but do not return to the weight of controls. RRS rats also show an exaggerated endocrine response to subsequent novel stressors. Studies described here tested the effects of corticotropin-releasing factor receptor (CRFR) antagonism on RRS-induced weight loss, hypophagia, and corticosterone release during mild stress in the postrestraint period. Weight loss was not prevented by either peripheral or third-ventricle administration of a CRFR1 antagonist, antalarmin, before each restraint. Antalarmin did, however, allow recovery of body weight in the poststress period. Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals. Surprisingly, third-ventricle administration of the nonselective CRFR antagonist, astressin, caused hypophagia and reversible weight loss in control rats. It had no effect in RRS rats. None of the antagonists modified the corticosterone response to RRS or to mild stress in the post-RRS period, but antalarmin suppressed corticosterone during the period of restraint in Control rats. These results suggest that CRFR1 activation is required for the initiation of events that lead to a prolonged down-regulation of body weight in RRS rats. The sustained reduction in body weight is independent of the severity of hypophagia on the days of restraint and of RRS-induced corticosterone release
机译：特定促肾上腺皮质激素释放因子受体亚型的拮抗作用选择性地改变了受约束大鼠的体重减轻。 Am J Physiol Regul Integr Comp Physiol 295：R1762-R1773，2008年。2008年10月15日首次发布; doi：10.1152 / ajpregu.00196.2008.-在3天（RRS）中的每3天受到束缚压力的老鼠在RRS的日子里会减轻体重，并在压力消除后以与对照组相同的速度增加体重，但不会恢复控件的重量。 RRS大鼠还表现出对随后的新型应激源的过度内分泌反应。此处描述的研究测试了肾上腺皮质激素释放因子受体（CRFR）拮抗作用对约束后后期轻度应激期间RRS引起的体重减轻，吞咽不足和皮质酮释放的影响。在每次束缚之前，不能通过外周或第三心室施用CRFR1拮抗剂antalarmin来防止体重减轻。但是，Antalarmin确实可以在应激后恢复体重。第三室施用CRFR2拮抗剂抗sauvagine 30对RRS大鼠无影响，但导致对照动物体重持续减轻。出人意料的是，第三脑室施用非选择性CRFR拮抗剂astressin在对照组大鼠中引起吞咽不足和可逆的体重减轻。它对RRS大鼠没有影响。在RRS后期间，没有一种拮抗剂能改变皮质酮对RRS或轻度压力的反应，但在控制大鼠的抑制期内，antalarmin抑制了皮质酮。这些结果表明CRFR1激活是引发RRS大鼠体重持续下调的事件所必需的。体重的持续减轻与束缚之日的吞咽不足的严重程度以及RRS诱导的皮质酮释放无关

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