Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.

Petzold T; Orr AW; Hahn C

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Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.

机译：黏着斑激酶通过在内皮细胞中的流动来调节NF-κB的活化。

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Atherogenesis involves activation of NF-kappaB in endothelial cells by fluid shear stress. Because this pathway involves integrins, we investigated the involvement of focal adhesion kinase (FAK). We found that FAK was not required for flow-stimulated translocation of the p65 NF-kappaB subunit to the nucleus but was essential for phosphorylation of p65 on serine 536 and induction of ICAM-1, an NF-kappaB-dependent gene. NF-kappaB activation by TNF-alpha or hydrogen peroxide was FAK independent. Events upstream of NF-kappaB, including integrin activation, Rac activation, reactive oxygen production, and degradation of IkappaB, were FAK independent. FAK therefore regulates NF-kappaB phosphorylation and transcriptional activity in response to flow by a novel mechanism.

机译：动脉粥样硬化涉及通过流体剪切应力激活内皮细胞中的NF-κB。由于此途径涉及整合素，因此我们研究了粘着斑激酶（FAK）的参与。我们发现，FAK并不是p65 NF-kappaB亚基流刺激转运到细胞核所必需的，但对于丝氨酸536上p65的磷酸化和ICA--1（一种依赖NF-kappaB的基因）的诱导是必不可少的。 TNF-α或过氧化氢对NF-κB的激活与FAK无关。 NF-κB上游的事件（包括整联蛋白激活，Rac激活，活性氧生成和IkappaB降解）与FAK无关。因此，FAK通过一种新颖的机制响应血流而调节NF-κB的磷酸化和转录活性。

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《American Journal of Physiology》 |2009年第1期|共9页
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Petzold T; Orr AW; Hahn C;
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1. Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells. [J] . Petzold T, Orr AW, Hahn C American Journal of Physiology . 2009,第4aPta1期

机译：局灶性粘附激酶通过内皮细胞流动调节NF-κB的活化。
2. Focal adhesion kinase phosphorylation in flow-activation of endothelial NF-kB. Focus on "Focal adhesion kinase modulates activation of NF-kB by flow in endothelial cells" [J] . Shu Chien, Jeng-Jiann Chiu, Yi-Shuan Li American Journal of Physiology . 2009,第4aPta1期

机译：内皮NF-Kb流动激活中的焦粘激酶磷酸化。专注于“局灶性粘附激酶通过内皮细胞流动调节NF-Kb的活化”
3. alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells. [J] . Urbinati C, Bugatti A, Giacca M, Journal of Cell Science . 2005,第Pta17期

机译：粘着斑激酶的α（v）β3整合素依赖性激活介导了HIV-1 Tat在内皮细胞中的NF-κB激活和运动活性。
4. Absolute Quantification of Phosphorylation on the Kinase Activation Loop of Focal Adhesion Kinase: A Biomarker of Src Activity [C] . Eugene Ciccimaro, Steven K. Hanks, Ian A Blair ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：局灶性粘合激酶激酶活化环磷酸化的绝对定量：SRC活性的生物标志物
5. The focal adhesion protein paxillin is necessary for the activation of focal adhesion kinase. [D] . Wade, Ramon. 2003

机译：粘着斑蛋白paxillin对于激活粘着斑激酶是必需的。
6. Focal adhesion kinase phosphorylation in flow-activation of endothelial NF-κB. Focus on Focal adhesion kinase modulates activation of NF-κB by flow in endothelial cells [O] . Shu Chien, Jeng-Jiann Chiu, Yi-Shuan Li -1

机译：内皮细胞NF-κB激活中的黏着斑激酶磷酸化。专注于黏着斑激酶通过内皮细胞的流动调节NF-κB的激活
7. Focal adhesion kinase phosphorylation in flow-activation of endothelial NF-κB. Focus on “Focal adhesion kinase modulates activation of NF-κB by flow in endothelial cells” [O] . Chien, Shu, Chiu, Jeng-Jiann, Li, Yi-Shuan 2009

机译：内皮细胞NF-κB激活中的黏着斑激酶磷酸化。专注于“黏着斑激酶通过内皮细胞的流动调节NF-κB的激活”

Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells.

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