• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization.
【24h】

In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization.

机译：MRI对小鼠腹主动脉血流模式的体内评估：对AAA定位的影响。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abdominal aortic aneurysms (AAA) localize in the infrarenal aorta in humans, while they are found in the suprarenal aorta in mouse models. It has been shown previously that humans experience a reversal of flow during early diastole in the infrarenal aorta during each cardiac cycle. This flow reversal causes oscillatory wall shear stress (OWSS) to be present in the infrarenal aorta of humans. OWSS has been linked to a variety of proatherogenic and proinflammatory factors. The presence of reverse flow in the mouse aorta is unknown. In this study we investigated blood flow in mice, using phase-contrast magnetic resonance (PCMR) imaging. We measured blood flow in the suprarenal and infrarenal abdominal aorta of 18 wild-type C57BL/6J mice and 15 apolipoprotein E (apoE)-/- mice. Although OWSS was not directly evaluated, results indicate that, unlike humans, there is no reversal of flow in the infrarenal aorta of wild-type or apoE-/- mice. Distensibility of the mouse aortic wall in both the suprarenal and infrarenal segments is higher than reported values for the human aorta. We conclude that normal mice do not experience the reverse flow in the infrarenal aorta that is observed in humans.
机译：腹主动脉瘤（AAA）位于人的肾下主动脉，而在小鼠模型中则位于肾上主动脉。先前已证明，在每个心动周期中，人类在肾下主动脉的早期舒张期经历血流逆转。这种流动逆转导致人的肾下主动脉中存在振荡壁切应力（OWSS）。 OWSS与多种促动脉粥样硬化和促炎因素有关。小鼠主动脉中是否存在逆流。在这项研究中，我们使用相衬磁共振（PCMR）成像技术研究了小鼠的血流。我们测量了18只野生型C57BL / 6J小鼠和15只载脂蛋白E（apoE）-/-小鼠的肾上和肾下腹主动脉的血流量。尽管未直接评估OWSS，但结果表明，与人类不同，野生型或apoE-/-小鼠的肾下主动脉血流没有逆转。肾上段和肾下段的小鼠主动脉壁的可扩张性高于人主动脉的报道值。我们得出的结论是，正常小鼠不会在人类中观察到肾下主动脉的逆流。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号