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首页> 外文期刊>American Journal of Physiology >L-Proline as a modulator of ectodermal differentiation in ES cells. Focus on 'L-Proline induces differentiation of ES cells: A novel role for an amino acid in the regulation of pluripotent cells in culture
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L-Proline as a modulator of ectodermal differentiation in ES cells. Focus on 'L-Proline induces differentiation of ES cells: A novel role for an amino acid in the regulation of pluripotent cells in culture

机译：L-脯氨酸作为ES细胞外胚层分化的调节剂。专注于“ L-脯氨酸诱导ES细胞分化：氨基酸在培养多能细胞调控中的新作用

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摘要

current research is focusing on defining the control of pluri-potency and lineage determination of pluripotent cells, particularly of embryonic stem (ES) cells. ES cells are usually produced from the inner cell mass (ICM) of the blastocyst and are considered equivalent to ICM cells captured during a short period of transient self-renewal and pluripotency capability. Nowadays, ES cells represent an incredible in vitro model to study critical aspects of cell sternness and early embryonic development. ES cells are indeed the only stem cell type able to self-renew indefinitely and to differentiate into cellular derivates of ectodermal, mesodermal, and endodermal lineages (8). Several studies in this matter have detailed on peculiar in vitro culturing protocols for ES cells, with the main effort to optimize ES cell pluripotency, maintenance, and controlled induction of differentiation (1, 6, 9).
机译：当前的研究集中在定义多潜能细胞的控制和多能细胞特别是胚胎干细胞的谱系确定。 ES细胞通常由胚泡的内部细胞团（ICM）产生，并被认为等同于在短暂的短暂自我更新和多能性能力中捕获的ICM细胞。如今，ES细胞代表了一种令人难以置信的体外模型，用于研究细胞干性和早期胚胎发育的关键方面。 ES细胞确实是唯一能够无限自我更新并分化为外胚层，中胚层和内胚层谱系细胞衍生物的干细胞类型（8）。在此问题上的一些研究详细介绍了ES细胞的体外培养方案，主要致力于优化ES细胞的多能性，维持和分化的受控诱导（1、6、9）。

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