首页> 外文期刊>American Journal of Physiology >From blood typing to a transport metabolon at a crossroad. Focus on Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae'.
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From blood typing to a transport metabolon at a crossroad. Focus on Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae'.

机译:从血型识别到十字路口的转运代谢物。着重研究(Oryzias latipes)幼虫线粒体富集细胞中铵依赖的钠吸收”。

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the rh blood group-related proteins have recently been recognized as ammonia transporters acting in erythrocyte and nonerythrocyte membranes. They play an important role in excretion of nitrogenous waste formed mainly from amino acid metabolism. Because of a restricted availability of water, most terrestrial animals detoxify ammonia into urea or uric acid before removal from the body. However, aquatic animals, living in an abundant supply of water, can directly excrete ammonia into the environment immediately as it is produced. This method of ammonia elimination is strategic in avoiding urea synthesis, an anabolic process requiring ATP. In this issue of American Journal of Physiology-Cell Physiology, Wu et al. (28) add a further twist to this adaptive strategy by providing evidence for a coupling of the ammonia excretion with a sodium uptake process, which is essential for living in freshwater conditions.
机译:最近,rh血型相关蛋白被认为是作用于红细胞和非红细胞膜的氨转运蛋白。它们在排泄主要由氨基酸代谢形成的含氮废物中起重要作用。由于水的供应有限,大多数陆生动物在将其从体内清除之前,先将氨解毒成尿素或尿酸。然而,生活在水源充足的水生动物可以在氨产生时立即将其直接排入环境。这种消除氨的方法在避免尿素合成(这是需要ATP的合成代谢过程)中具有战略意义。在《美国生理学-细胞生理学杂志》这一期中,Wu等人。 (28)通过提供氨排泄与钠吸收过程耦合的证据,为这种适应性策略增加了进一步的扭曲,这对于生活在淡水条件下至关重要。

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