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首页> 外文期刊>American Journal of Physiology >Limited predictive ability of surrogate indices of insulin sensitivity/resistancein Asian-Indian men.
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Limited predictive ability of surrogate indices of insulin sensitivity/resistancein Asian-Indian men.

机译：亚洲-印度裔男性中胰岛素敏感性/抵抗力替代指标的预测能力有限。

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Insulin resistance is highly prevalent in Asian Indians and contributes toworldwide public health problems, including diabetes and related disorders.Surrogate measurements of insulin sensitivity/resistance are used frequently tostudy Asian Indians, but these are not formally validated in this population. In this study, we compared the ability of simple surrogate indices to accuratelypredict insulin sensitivity as determined by the reference glucose clamp method. In this cross-sectional study of Asian-Indian men (n = 70), we used a calibrationmodel to assess the ability of simple surrogate indices for insulin sensitivity[quantitative insulin sensitivity check index (QUICKI), homeostasis modelassessment (HOMA2-IR), fasting insulin-to-glucose ratio (FIGR), and fastinginsulin (FI)] to predict an insulin sensitivity index derived from the reference glucose clamp method (SI(Clamp)). Predictive accuracy was assessed by both rootmean squared error (RMSE) of prediction as well as leave-one-outcross-validation-type RMSE of prediction (CVPE). QUICKI, FIGR, and FI, but notHOMA2-IR, had modest linear correlations with SI(Clamp) (QUICKI: r = 0.36; FIGR: r = -0.36; FI: r = -0.27; P < 0.05). No significant differences were noted among CVPE or RMSE from any of the surrogate indices when compared with QUICKI.Surrogate measurements of insulin sensitivity/resistance such as QUICKI, FIGR,and FI are easily obtainable in large clinical studies, but these may only beuseful as secondary outcome measurements in assessing insulinsensitivity/resistance in clinical studies of Asian Indians.
机译：胰岛素抵抗在亚洲印第安人中非常普遍，并导致全世界的公共卫生问题，包括糖尿病和相关疾病。对胰岛素敏感性/抵抗力的替代性测量经常用于研究亚洲印第安人，但是在这些人群中尚未对此进行正式验证。在这项研究中，我们比较了简单替代指标通过参考葡萄糖钳夹法确定的准确预测胰岛素敏感性的能力。在这项对亚裔和印度裔男性（n = 70）的横断面研究中，我们使用了一个校准模型来评估简单的替代指标的胰岛素敏感性[定量胰岛素敏感性检查指数（QUICKI），体内稳态模型评估（HOMA2-IR），空腹胰岛素与葡萄糖之比（FIGR）和空腹胰岛素（FI）]，以预测从参考葡萄糖钳制方法（SI（Clamp））得出的胰岛素敏感性指数。预测准确性通过预测的均方根误差（RMSE）以及预测的留一交叉验证型RMSE（CVPE）进行评估。 QUICKI，FIGR和FI，但不是HOMA2-IR，与SI（Clamp）具有适度的线性相关性（QUICKI：r = 0.36; FIGR：r = -0.36; FI：r = -0.27; P <0.05）。与QUICKI相比，CVPE或RMSE的任何替代指标之间均无显着差异。在大型临床研究中可以轻松获得胰岛素敏感性/耐药性（例如QUICKI，FIGR和FI）的替代指标，但这些指标仅可作为继发指标在亚洲印第安人的临床研究中评估胰岛素敏感性/抵抗力的预后评估。

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