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首页> 外文期刊>American Journal of Physiology >Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice.
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Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice.

机译：VIP受体2缺陷小鼠的运动活动，心律，心律和核心体温的时间阶段被破坏。

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摘要

Neurons of the brain's biological clock located in the hypothalamic suprachiasmatic nucleus (SCN) generate circadian rhythms of physiology (core body temperature, hormone secretion, locomotor activity, sleep/wake, and heart rate) with distinct temporal phasing when entrained by the light/dark (LD) cycle. The neuropeptide vasoactive intestinal polypetide (VIP) and its receptor (VPAC2) are highly expressed in the SCN. Recent studies indicate that VIPergic signaling plays an essential role in the maintenance of ongoing circadian rhythmicity by synchronizing SCN cells and by maintaining rhythmicity within individual neurons. To further increase the understanding of the role of VPAC2 signaling in circadian regulation, we implanted telemetric devices and simultaneously measured core body temperature, spontaneous activity, and heart rate in a strain of VPAC2-deficient mice and compared these observations with observations made from mice examined by wheel-running activity. The study demonstrates that VPAC2 signaling is necessary for a functional circadian clock driving locomotor activity, core body temperature, and heart rate rhythmicity, since VPAC2-deficient mice lose the rhythms in all three parameters when placed under constant conditions (of either light or darkness). Furthermore, although 24-h rhythms for three parameters are retained in VPAC2-deficient mice during the LD cycle, the temperature rhythm displays markedly altered time course and profile, rising earlier and peaking approximately 4-6 h prior to that of wild-type mice. The use of telemetric devices to measure circadian locomotor activity, temperature, and heart rate, together with the classical determination of circadian rhythms of wheel-running activity, raises questions about how representative wheel-running activity may be of other behavioral parameters, especially when animals have altered circadian phenotype.
机译：大脑位于下丘脑上视交叉上核（SCN）的生物钟的神经元会产生生理学的昼夜节律（核心体温，激素分泌，运动活动，睡眠/觉醒和心律），当受到明/暗夹带时，它们具有明显的时间相位（LD）周期。神经肽血管活性肠多肽（VIP）及其受体（VPAC2）在SCN中高度表达。最近的研究表明，通过同步SCN细胞并通过维持单个神经元的节律性，VIPergic信号在维持正在进行的昼夜节律性中起着至关重要的作用。为了进一步了解VPAC2信号在昼夜节律调节中的作用，我们植入了遥测设备，同时测量了VPAC2缺陷小鼠品系的核心体温，自发活动和心率，并将这些观察结果与所检查小鼠的观察结果进行了比较通过车轮行驶活动。研究表明，VPAC2信号对于驱动运动活动，核心体温和心律律性的功能性生物钟是必需的，因为当将VPAC2缺乏的小鼠置于恒定条件下（明亮或黑暗）时，所有三个参数均失去节奏。此外，尽管LD周期中在VPAC2缺失的小鼠中保留了三个参数的24小时节律，但温度节律显示出明显的时程和轮廓改变，比野生型小鼠早且上升约4-6小时达到峰值。使用遥测设备来测量昼夜运动能力，温度和心率，以及经典的轮转活动昼夜节律确定，引起了人们对代表性轮转活动如何具有其他行为参数的疑问，尤其是在动物身上改变了昼夜节律表型。

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