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首页> 外文期刊>American Journal of Physiology >Mitochondrial capacity is affected by glycemic status in young untrained women with type 1 diabetes but is not impaired relative to healthy untrained women.
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Mitochondrial capacity is affected by glycemic status in young untrained women with type 1 diabetes but is not impaired relative to healthy untrained women.

机译：在未经训练的年轻1型糖尿病女性中，线粒体能力受血糖状况的影响，但相对于未经训练的健康女性，线粒体能力并未受到损害。

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In this study, we examined whether glycemic status influences aerobic function in women with type 1 diabetes and whether aerobic function is reduced relative to healthy women. To this end, we compared several factors determining aerobic function of 29 young sedentary asymptomatic women (CON) with 9 women of similar age and activity level with type 1 diabetes [DIA, HbA1c range = 6.9-8.2%]. Calf muscle mitochondrial capacity was estimated by (31)P-magnetic resonance spectroscopy. Capillarization and muscle fiber oxidative enzyme activity were assessed from vastus lateralis and soleus muscle biopsies. Oxygen uptake and cardiac output were evaluated by ergospirometry and N(2)O/SF(6) rebreathing. Calf muscle mitochondrial capacity was not different between CON and DIA, as indicated by the identical calculated maximal rates of oxidative ATP synthesis [0.0307 (0.0070) vs. 0.0309 (0.0058) s(-1), P = 0.930]. Notably, HbA1c was negatively correlated with mitochondrial capacity in DIA (R(2) = 0.475, P = 0.040). Although HbA1c was negatively correlated with cardiac output (R(2) = 0.742, P = 0.013) in DIA, there was no difference between CON and DIA in maximal oxygen consumption [2.17 (0.34) vs. 2.21 (0.32) l/min, P = 0.764], cardiac output [12.1 (1.9) vs. 12.3 (1.8) l/min, P = 0.783], and endurance capacity [532 (212) vs. 471 (119) s, P = 0.475]. There was also no difference between the two groups either in the oxidative enzyme activity or capillary-to-fiber ratio. We conclude that mitochondrial capacity depends on HbA1c in untrained women with type 1 diabetes but is not reduced relative to untrained healthy women.
机译：在这项研究中，我们检查了血糖状况是否影响1型糖尿病女性的有氧功能，以及相对于健康女性，有氧功能是否降低。为此，我们比较了确定29位久坐无症状的年轻女性（CON）和9位年龄和活动水平与1型糖尿病相似的女性的有氧功能的几个因素[DIA，HbA1c范围= 6.9-8.2％]。小腿肌肉线粒体容量由（31）P磁共振波谱法估计。从股外侧肌和比目鱼肌活组织检查中评估毛细血管化和肌纤维氧化酶活性。氧摄取和心输出量通过人体工程肺量计和N（2）O / SF（6）呼吸进行评估。小腿肌线粒体能力在CON和DIA之间没有差异，如氧化ATP合成的最大计算相同速率所表明的[0.0307（0.0070）vs. 0.0309（0.0058）s（-1），P = 0.930]。值得注意的是，HbA1c与DIA中的线粒体能力呈负相关（R（2）= 0.475，P = 0.040）。尽管DIA中HbA1c与心输出量呈负相关（R（2）= 0.742，P = 0.013），但CON和DIA的最大耗氧量没有差异[2.17（0.34）vs. 2.21（0.32）l / min， P = 0.764]，心输出量[12.1（1.9）对12.3（1.8）l / min，P = 0.783]和耐力[532（212）对471（119）s，P = 0.475]。两组之间的氧化酶活性或毛细管纤维比率均无差异。我们得出的结论是，未经训练的1型糖尿病女性的线粒体能力取决于HbA1c，但相对于未经训练的健康女性，线粒体能力并未降低。

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