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首页> 外文期刊>American Journal of Physiology >High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats.
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High-fat diet offsets the long-lasting effects of running-wheel access on food intake and body weight in OLETF rats.

机译：高脂饮食抵消了滚轮进入对OLETF大鼠食物摄入和体重的长期影响。

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We have previously demonstrated that running-wheel access normalizes the food intake and body weight of Otsuka Long-Evens Tokushima Fatty (OLETF) rats. Following 6 wk of running-wheel access beginning at 8 wk of age, the body weight of OLETF rats remains reduced, demonstrating a lasting effect on their phenotype. In contrast, access to a high-fat diet exacerbates the hyperphagia and obesity of OLETF rats. To determine whether diet modulates the long-term effects of exercise, we examined the effects of high-fat diet on food intake and body weight in OLETF rats that had prior access to running wheels for 4 wk. We found that 4 wk of running exercise significantly decreased food intake and body weight of OLETF rats. Consistent with prior results, 4 wk of exercise also produced long-lasting effects on food intake and body weight in OLETF rats fed a regular chow. When running wheels were relocked, OLETF rats stabilized at lower levels of body weight than sedentary OLETF rats. However, access to a high-fat diet offset these effects. When OLETF rats were switched to a high-fat diet following wheel relocking, they significantly increased food intake and body weight, so that they reached levels similar to those of sedentary OLETF rats fed a high-fat diet. Gene expression determination of hypothalamic neuropeptides revealed changes that appeared to be appropriate responses to the effects of diet and running exercise. Together, these results demonstrate that high-fat diet modulates the long-lasting effects of exercise on food intake and body weight in OLETF rats.
机译：先前我们已经证明，运行轮的进入可以使大冢长寿德岛胖子（OLETF）大鼠的食物摄入量和体重正常化。在8周龄开始行走6周后，OLETF大鼠的体重仍然降低，这表明其表型具有持久作用。相反，获得高脂饮食会加剧OLETF大鼠的食欲亢进和肥胖。为了确定饮食是否能调节运动的长期效果，我们检查了高脂饮食对OLETF大鼠的饮食和体重的影响，这些大鼠先前已经使用了4 wk的滚轮。我们发现4周跑步锻炼显着降低了OLETF大鼠的食物摄入量和体重。与之前的结果一致，进行4周的运动对喂食普通食物的OLETF大鼠的食物摄入和体重也产生了持久的影响。重新锁紧工作轮后，OLETF大鼠的体重比久坐的OLETF大鼠稳定。但是，获得高脂饮食可以抵消这些影响。车轮重新锁定后，当OLETF大鼠改用高脂饮食时，它们会显着增加食物摄入量和体重，因此其水平与久坐的高脂饮食OLETF大鼠相似。下丘脑神经肽的基因表达测定揭示了变化，似乎是对饮食和跑步运动的适当反应。总之，这些结果表明，高脂饮食可以调节运动对OLETF大鼠食物摄入和体重的持久影响。

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