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首页> 外文期刊>American Journal of Physiology >Function without form: an ongoing search for maxi-anion channel proteins. Focus on 'Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells'
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Function without form: an ongoing search for maxi-anion channel proteins. Focus on 'Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells'

机译：没有形式的功能：不断寻找最大阴离子通道蛋白。专注于“ Maxi-阴离子通道和pannexin 1半通道构成在小鼠L929纤维肉瘤细胞中溶胀诱导的ATP释放的独立途径”

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given the established roles for extracellular ATP and other nucleotides as mediators of paracrine or autocrine signaling in most tissues, much current research in the purinergic arena seeks to define the mechanisms by which intracellular nucleotides are exported to extracellular compartments. (See Ref. 6 for a concise but comprehensive summary of ATP release biology.) Although direct cytolysis is an obvious source of extracellular ATP in the setting of traumatic tissue injury, several pathways can be mobilized to release nucleotides from intact cells (Fig. 1). These include exocytosis of nucleotides compartmentalized within 1) the Golgi-derived vesicles used for constitutive secretion of glycoproteins from most cells; or 2) the vesicles and granules used for Ca~(2+)-dependent regulated secretion of neurotransmitters and hormones from specialized secretory cells and tissues that include neurons, glia, platelets, endocrine glands, and exocrine glands. Most mammalian cell types also exhibit an increased rate of ATP export in response to various non-lytic mechanical stimuli, which include hypo-tonic stress-induced cell swelling, direct deformation of the surface membrane, fluid shear stress, or agonists for G protein-coupled receptors that regulate membrane-cytoskeletal rearrangements.
机译：鉴于细胞外ATP和其他核苷酸在大多数组织中作为旁分泌或自分泌信号传导介质的已确立的作用，嘌呤能领域中的许多最新研究试图确定细胞内核苷酸输出到细胞外区室的机制。 （有关ATP释放生物学的简要但全面的概述，请参见参考文献6。）尽管直接细胞溶解是创伤性组织损伤中细胞外ATP的明显来源，但可以动员多种途径从完整细胞中释放核苷酸（图1）。 ）。这些包括胞外核苷酸的胞吐作用：1）高尔基衍生的囊泡，用于从大多数细胞组成性分泌糖蛋白;或2）用于从特定的分泌性细胞和组织（包括神经元，神经胶质，血小板，内分泌腺和外分泌腺）分泌Ca〜（2+）依赖性神经递质和激素的调节性分泌的囊泡和颗粒。大多数哺乳动物细胞类型还可以响应各种非溶解性机械刺激而增加ATP的输出速率，这些刺激包括低渗应激诱导的细胞肿胀，表面膜直接变形，流体剪切应力或G蛋白激动剂。调节膜细胞骨架重排的偶联受体。

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