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首页> 外文期刊>American Journal of Physiology >gffect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes
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gffect of aging on norepinephrine-related proliferative response in primary cultured periportal and perivenous hepatocytes

机译：衰老对原代培养的门静脉和静脉肝细胞中去甲肾上腺素相关增殖反应的影响

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Transglutaminase 2 (TG2) is known as a multifunction enzyme. GTPase activity of TG2 acts as an a-subunit of Gh protein coupled with aiB-adrenergic receptor mediating the activation of PLC-7I (rather than the PLC-`amily) and inositol phosphate production in response to adrenergic agonists such as epinephrine and phenylephrine. As a protein cross-linker, TG2 also catalyzes a calcium-dependent cross-linking reaction through the formation of ?-glutamyl) lysine isopeptide bonds. (2, 29, 51). The GTP/GDP binding of TG2 has been shown to be involved in regulation of cell cycle progression. In contrast, the Ca~(2+)-dependent cross-linking activity of TG2 contributes to the remodeling of the extracellular matrix and to the inhibition of cell growth (1, 50). Additionally, Ca~(2+)-activated TG2 interacts and modifies various intracellular and intranuclear proteins such as RhoA and pRB, respectively (30, 43). These two distinct functions of TG2 are switched with the binding of either GTP or Ca~(2+) to itself (10). TG2 is more highly expressed in hepatocytes. Indeed, EGFR was modified by TG2, resulting in the restriction of dimerization and the autophosphorylation of EGFR in rat hepatocytes (25).
机译：转谷氨酰胺酶2（TG2）被称为多功能酶。 TG2的GTPase活性是Gh蛋白的一个亚基，与aiB-肾上腺素受体偶联，介导PLC-7I的活化（而不是PLC-家族）和肌醇磷酸生成，以响应肾上腺素能激动剂（如肾上腺素和去氧肾上腺素）。作为蛋白质交联剂，TG2还通过形成β-谷氨酰赖氨酸异肽键来催化钙依赖性交联反应。 （2，29，51）。已经显示TG2的GTP / GDP结合参与细胞周期进程的调节。相反，TG2的Ca〜（2+）依赖性交联活性有助于细胞外基质的重塑和细胞生长的抑制（1，50）。此外，Ca〜（2+）激活的TG2相互作用并修饰各种细胞内和核内蛋白，例如RhoA和pRB（30，43）。 TG2的这两个不同功能是通过GTP或Ca〜（2+）与其自身的结合而转换的（10）。 TG2在肝细胞中更高的表达。实际上，EGFR被TG2修饰，导致大鼠肝细胞中EGFR的二聚化和自磷酸化受到限制（25）。

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