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首页> 外文期刊>American Journal of Physiology >PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans
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PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans

机译：PET成像显示非肥胖人群不同区域脂肪组织贮库在全身性葡萄糖代谢中的独特作用

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摘要

Excess amounts of abdominal subcutaneous (SAT) and visceral (VAT) adipose tissue (AT) are associated with insulin resistance, even in normal-weight subjects. In contrast, gluteal-femoral AT (GFAT) is hypothesized to offer protection against insulin resistance. Dynamic PET imaging studies were undertaken to examine the contributions of both metabolic activity and size (volume) of these depots in systemic glucose metabolism. Nonobese, healthy volunteers (n = 15) underwent dynamic PET imaging uptake of [~(18)F]FDG at a steady-state (20 mU.m~(-2).min~(-1)) insulin infusion. PET images of tissue [~(18)F]FDG activity were coreg-istered with MRI to derive K values for insulin-stimulated rates of fractional glucose uptake within tissue. Adipose tissue volume was calculated from DEXA and MRI. VAT had significantly higher rates of fractional glucose uptake per volume than SAT (P < 0.05) or GFAT (P < 0.01). Kgfat correlated positively (r = 0.67, P < 0.01) with systemic insulin sensitivity [glucose disappearance rate (Rd)] and negatively with insulin-suppressed FFA (r = -0.71, P < 0.01). SAT (r = -0.70, P < 0.01) and VAT mass (r = -0.55, P < 0.05) correlated negatively with R_d, but GFAT mass did not. We conclude that rates of fractional glucose uptake within GFAT and VAT are significantly and positively associated with systemic insulin sensitivity in nonobese subjects. Furthermore, whereas SAT and VAT amounts are confirmed to relate to systemic insulin resistance, GFAT amount is not associated with insulin resistance. These dynamic PET imaging studies indicate that both quantity and quality of specific AT depots have distinct roles in systemic insulin resistance and may help explain the metabolically obese but normal-weight phenotype.
机译：即使在体重正常的受试者中，过量的腹部皮下（SAT）和内脏（VAT）脂肪组织（AT）也与胰岛素抵抗相关。相比之下，假设臀股动脉AT（GFAT）可提供针对胰岛素抵抗的保护作用。进行了动态PET成像研究，以检查这些贮库的代谢活性和大小（体积）在全身性葡萄糖代谢中的贡献。非肥胖健康志愿者（n = 15）在稳态（20 mU.m〜（-2）.min〜（-1））胰岛素输注下动态摄取[〜（18）F] FDG的PET显像。将组织[〜（18）F] FDG活性的PET图像与MRI核对，得出胰岛素刺激的组织内部分葡萄糖摄取率的K值。脂肪组织体积由DEXA和MRI计算得出。与SAT（P <0.05）或GFAT（P <0.01）相比，增值税的每体积分数葡萄糖摄取率显着更高。 Kgfat与全身胰岛素敏感性[葡萄糖消失率（Rd）]正相关（r = 0.67，P <0.01），与胰岛素抑制的FFA呈负相关（r = -0.71，P <0.01）。 SAT（r = -0.70，P <0.01）和VAT质量（r = -0.55，P <0.05）与R_d呈负相关，但GFAT质量没有。我们得出结论，在非肥胖受试者中，GFAT和VAT中的部分葡萄糖摄取率与全身胰岛素敏感性显着正相关。此外，尽管已确认SAT和VAT量与全身胰岛素抵抗有关，但GFAT量与胰岛素抵抗无关。这些动态PET成像研究表明，特定AT库的数量和质量在系统性胰岛素抵抗中具有不同的作用，并且可能有助于解释代谢性肥胖但体重正常的表型。

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