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首页> 外文期刊>Analytical chemistry >Electrospray-Assisted Laser Desorption/lonization Mass Spectrometry for Continuously Monitoring the States of Ongoing Chemical Reactions in Organic or Aqueous Solution under Ambient Conditions
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Electrospray-Assisted Laser Desorption/lonization Mass Spectrometry for Continuously Monitoring the States of Ongoing Chemical Reactions in Organic or Aqueous Solution under Ambient Conditions

机译：电喷雾辅助激光解吸/电离质谱法在环境条件下连续监测有机或水溶液中正在进行的化学反应的状态

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摘要

Electrospray-assisted laser desorption/ionization (ELDI) combined with mass spectrometry allows chemical and biochemical compounds to be characterized directly from hydrophilic and hydrophobic organic solutions mixed with carbon powders under ambient conditions. Organic and inorganic compounds dissolved in polar or nonpolar solvent such as methanol, tetrahydrofuran, ethyl acetate, toluene, dichloromethane, or hexane can be detected using this ambient ionization technique without prior pretreatment. We have used this technique to monitor the progress in several ongoing reactions: the epoxidation of chalcone in ethanol, the chelation of ethylenediaminetetraacetic acid with copper and nickel ions in aqueous solution, the chelation of 1,10-phenanthroline with iron(II) in methanol, and the tryptic digestion of cytochrome c in aqueous solution. Liquid-ELDI analyses simply require irradiation of the surface of the sample solution with a pulsed ultraviolet laser; the laser energy is adsorbed by the carbon powder presuspended in the sample solution; the absorbed laser energy is then transferred to the surrounding solvent and to the analyte molecules in the solution, leading to their desorption; the desorbed gaseous analyte molecules are then postionized within an electrospray (ESI) plume to generate ESI-like analyte ions.
机译：电喷雾辅助激光解吸/电离（ELDI）与质谱相结合，可以在环境条件下直接从与碳粉混合的亲水和疏水有机溶液中表征化学和生化化合物。使用这种环境电离技术，无需事先进行预处理，即可检测出溶解在极性或非极性溶剂（例如甲醇，四氢呋喃，乙酸乙酯，甲苯，二氯甲烷或己烷）中的有机和无机化合物。我们已经使用该技术监测了几个正在进行的反应的进展：乙醇中查尔酮的环氧化，水溶液中铜和镍离子与乙二胺四乙酸的螯合，甲醇中铁（II）与1,10-菲咯啉的螯合，以及水溶液中细胞色素c的胰蛋白酶消化。液体ELDI分析仅需要用脉冲紫外激光照射样品溶液的表面即可。激光能量被样品溶液中预先悬浮的碳粉吸收;吸收的激光能量然后转移到周围的溶剂和溶液中的分析物分子，导致其解吸;然后将解吸的气态分析物分子在电喷雾（ESI）羽流中进行离子化处理，生成类似ESI的分析物离子。

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