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首页> 外文期刊>Analytical chemistry >Exploitation of Nano Alumina for the Chromatographic Separation of Clinical Grade ~(188)Re from ~(188)W: A Renaissance of the ~(188)W/~(188)Re Generator Technology
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Exploitation of Nano Alumina for the Chromatographic Separation of Clinical Grade ~(188)Re from ~(188)W: A Renaissance of the ~(188)W/~(188)Re Generator Technology

机译：利用纳米氧化铝从〜（188）W色谱分离临床级〜（188）Re：〜（188）W /〜（188）Re发生器技术的复兴

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The ~(188)W/~(188)Re generator using an acidic alumina column for chromatographic separation of ~(188)Re has remained the most popular procedure world over. The capacity of bulk alumina for taking up tungstate ions is limited (approx50 mg W/g) necessitating the use of very high specific activity ~(188)W (185-370 GBq/g), which can be produced only in very few high flux reactors available in the world. In this context, the use of high-capacity sorbents would not only mitigate the requirement of high specific activity ~(188)W but also facilitate easy access to ~(188)Re. A solid state mechanochemical approach to synthesize nanocrystalline gamma-Al_(2)O_(3) possessing very high W-sorption capacity (500 mg W/g) was developed. The structural and other investigations of the material were carried out using X-ray diffraction (XRD), transmission electron microscopy (TEM), Brunauer Emmett Teller (BET) surface area analysis, thermogravimetric-differential thermal analysis (TG-DTA), and dynamic light scattering (DLS) techniques. The synthesized material had an average crystallite size of approx5 nm and surface area of 252 +- 10 m~(2)/g. Sorption characteristics such as distribution ratios (K_(d)), capacity, breakthrough profile, and elution behavior were investigated to ensure quantitative uptake of ~(188)W and selective elution of ~(188)Re. A 11.1 GBq (300 mCi) ~(188)W/~(188)Re generator was developed using nanocrystalline gamma-Al_(2)O_(3), and its performance was evaluated for a period of 6 months. The overall yield of ~(188)Re was >80percent, with >99.999percent radionuclidic purity and >99percent radiochemical purity. The eluted ~(188)Re possessed appreciably high radioactive concentration and was compatible for the preparation of ~(188)Re labeled radiopharmaceuticals.
机译：使用酸性氧化铝柱色谱分离〜（188）Re的〜（188）W /〜（188）Re生成器一直是全世界最受欢迎的程序。散装氧化铝吸收钨酸根离子的能力有限（大约50 mg W / g），因此必须使用非常高的比活〜（188）W（185-370 GBq / g），只有极高的比活才能产生世界上可以买到的磁通反应器。在这种情况下，使用高容量吸附剂不仅可以减轻对〜（188）W的高比活度的需求，而且还可以轻松获得〜（188）Re。开发了一种固态机械化学方法来合成具有非常高的W吸附能力（500 mg W / g）的纳米晶体γ-Al_（2）O_（3）。使用X射线衍射（XRD），透射电子显微镜（TEM），Brunauer Emmett Teller（BET）表面积分析，热重-差热分析（​​TG-DTA）和动态方法对材料进行结构和其他研究光散射（DLS）技术。合成的材料具有约5nm的平均微晶尺寸和252±10m 2（g）/ g的表面积。研究了吸附特性，例如分布比（K_（d）），容量，突破曲线和洗脱行为，以确保〜（188）W的定量吸收和〜（188）Re的选择性洗脱。使用纳米晶γ-Al_（2）O_（3）开发了11.1 GBq（300 mCi）〜（188）W /〜（188）Re发生器，并对其性能进行了6个月的评估。 〜（188）Re的总收率> 80％，放射性核素纯度> 99.999％，放射化学纯度> 99％。洗脱的〜（188）Re具有较高的放射性浓度，与〜（188）Re标记的放射性药物的制备相容。

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