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首页> 外文期刊>Analytical chemistry >Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells
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Construction of Epidermal Growth Factor Receptor Peptide Magnetic Nanovesicles with Lipid Bilayers for Enhanced Capture of Liver Cancer Circulating Tumor Cells

机译：具有脂质双层的表皮生长因子受体肽磁性纳米囊泡的构建，以增强捕获肝癌循环肿瘤细胞的能力

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Highly effective targeted tumor recognition via vectors is crucial for cancer detection In contrast to antibodies and proteins, peptides are direct targeting ligands with a low molecular weight. In the present study, a peptide magnetic nanovector platform containing a lipid bilayer was designed using a peptide amphiphile (PA) as a skeleton material in a controlled manner without surface modification. Fluorescein isothiocyanate-labeled epidermal growth factor receptor (EGFR) peptide nanoparticles (NPs) could specifically bind to EGFR-positive liver tumor cells. EGFR peptide magnetic vesicles (EPMVs) could efficiently recognize and separate hepatoma carcinoma cells from cell solutions and treated blood samples (ratio of magnetic EPMVs versus anti-EpCAM NPs: 3.5 +/- 0.29). Analysis of the circulating tumor cell (CTC) count in blood samples from 32 patients with liver cancer showed that EPMVs Could be effectively applied for CTC capture. Thus, this nanoscale, targeted cargo-packaging technology may be useful for designing cancer diagnostic systems.
机译：通过载体的高效靶向肿瘤识别对于癌症检测至关重要。与抗体和蛋白质相反，肽是具有低分子量的直接靶向配体。在本研究中，使用肽两亲物（PA）作为骨架材料，以可控制的方式设计了包含脂质双层的肽磁性纳米载体平台，无需进行表面修饰。异硫氰酸荧光素标记的表皮生长因子受体（EGFR）肽纳米颗粒（NPs）可以特异性结合EGFR阳性的肝肿瘤细胞。 EGFR肽磁泡（EPMV）可以从细胞溶液和经过处理的血样中有效识别并分离出肝癌癌细胞（磁性EPMV与抗EpCAM NP的比率：3.5 +/- 0.29）。对32例肝癌患者血液样本中循环肿瘤细胞（CTC）计数的分析表明，EPMV可有效应用于CTC捕获。因此，这种纳米级的目标货物包装技术可能对设计癌症诊断系统有用。

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