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首页> 外文期刊>Cortex: A Journal Devoted to the Study of the Nervous System and Behavior >Domain-independent neural underpinning of task-switching: An fMRI investigation
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Domain-independent neural underpinning of task-switching: An fMRI investigation

机译：任务切换的独立于域的神经基础：功能磁共振成像研究

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The ability to shift between different tasks according to internal or external demands, which is at the core of our behavioral flexibility, has been generally linked to the functionality of left fronto-parietal regions. Traditionally, the left and right hemispheres have also been associated with verbal and spatial processing, respectively. We therefore investigated with functional MRI whether the processes engaged during task-switching interact in the brain with the domain of the tasks to be switched, that is, verbal or spatial. Importantly, physical stimuli were exactly the same and participants' performance was matched between the two domains. The fMRI results showed a clearly left-lateralized involvement of fronto-parietal regions when contrasting task-switching versus single task blocks in the context of verbal rules. A more bilateral pattern, especially in the prefrontal cortex, was instead observed for switching between spatial tasks. Moreover, while a conjunction analysis showed that the core regions involved in task-switching, independently of the switching context, were localized both in left inferior prefrontal and parietal cortices and in bilateral supplementary motor area, a direct analysis of functional lateralization revealed that hemispheric asymmetries in the frontal lobes were more biased toward the left side for the verbal domain than for the spatial one and vice versa. Overall, these findings highlight the role of left frontoparietal regions in task-switching, above and beyond the specific task requirements, but also show that hemispheric asymmetries may be modulated by the more specific nature of the tasks to be performed during task-switching. (C) 2015 Elsevier Ltd. All rights reserved.
机译：根据内部或外部需求在不同任务之间切换的能力是我们行为灵活性的核心，通常已与左额顶区的功能联系在一起。传统上，左半球和右半球也分别与语言和空间处理相关联。因此，我们使用功能性MRI研究了任务转换过程中参与的过程是否在大脑中与要转换的任务域（即语言或空间）交互作用。重要的是，身体刺激完全相同，并且参与者的表现在两个领域之间是匹配的。 fMRI结果显示，在口头规则的情况下，对比任务转换与单个任务块时，额叶顶叶区域明显偏左。取而代之的是观察到更双边的模式，尤其是在前额叶皮层中，从而在空间任务之间切换。此外，尽管一项联结分析显示，与任务切换无关的任务切换所涉及的核心区域都位于左下额叶前额叶和顶叶皮层以及双侧辅助运动区，但对功能性偏侧化的直接分析显示，半球不对称对于空间域，额叶中的叶比在空间叶中偏向左侧，反之亦然。总的来说，这些发现突出了左前额叶区域在任务转换中的作用，超出了特定任务要求，而且还表明，在任务转换过程中要执行的任务的更具体性质可能会调节半球不对称性。 （C）2015 Elsevier Ltd.保留所有权利。

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