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首页> 外文期刊>Analytica chimica acta >Evaluation of false positive responses by mass spectrometry and ion mobility spectrometry for the detection of trace explosives in complex samples
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Evaluation of false positive responses by mass spectrometry and ion mobility spectrometry for the detection of trace explosives in complex samples

机译：通过质谱和离子迁移谱法评估假阳性反应，以检测复杂样品中的痕量炸药

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摘要

Secondary electrospray ionization-ion mobility-time of flight mass spectrometry (SESI-IM-TOFMS) was used to evaluate common household products and food ingredients for any mass or mobility responses that produced false positives for explosives. These products contained ingredients which shared the same mass and mobility drift time ranges as the analyte ions for common explosives. The results of this study showed that the vast array of compounds in these products can cause either mass or mobility false positive responses. This work also found that two ingredients caused either enhanced or reduced ionization of the target analytes. Another result showed that an IMS can provide real-time separation of ion species that impede accurate mass identifications due to overlapping isotope peak patterns. The final result of this study showed that, when mass and mobility values were used to identify an ion, no false responses were found for the target explosives. The wider implication of these results is that the possibility exists for even greater occurrences of false responses from complex mixtures found in common products. Neither IMS nor MS alone can provide 100% assurance from false responses. IMS, due to its low cost, ease of operation, rugged reliability, high sensitivity and tunable selectivity, will remain the field method of choice for the near future but, when combined with MS, can also reduce the false positive rate for explosive analyses.
机译：二次电喷雾电离离子迁移时间飞行质谱（SESI-IM-TOFMS）用于评估常见的家用产品和食品成分的质量或迁移率反应，该反应会产生爆炸性假阳性。这些产品所含成分的质量和迁移率漂移时间范围与普通炸药的分析物离子相同。这项研究的结果表明，这些产品中的大量化合物均可引起质量或迁移率的假阳性反应。这项工作还发现，两种成分导致目标分析物的离子化增强或降低。另一个结果表明，IMS可以提供​​离子种类的实时分离，这由于重叠的同位素峰图案而妨碍了准确的质量鉴定。这项研究的最终结果表明，当使用质量和迁移率值识别离子时，没有发现目标炸药有错误反应。这些结果具有更广泛的含义，即存在由普通产品中发现的复杂混合物引起误响应的可能性更大的可能性。 IMS和MS不能单独提供100％的错误响应保证。由于IMS的低成本，易操作性，坚固的可靠性，高灵敏度和可调的选择性，在不久的将来仍将是首选的现场方法，但​​是当与MS结合使用时，还可降低爆炸性分析的假阳性率。

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