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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Impact of Radical Surgery on Outcome in Locally Advanced Breast Cancer Patients Without Metastasis at the Time of Diagnosis
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Impact of Radical Surgery on Outcome in Locally Advanced Breast Cancer Patients Without Metastasis at the Time of Diagnosis

机译：根治术对诊断时无转移的局部晚期乳腺癌患者结局的影响

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Background/Aim: In the era of F-18-fluorodeoxy-glucose positron emission tomography/computed tomography ((18)FDG-PET/CT), more patients are being diagnosed with N3M0 disease. The objective of this study was to assess the prognostic impact of radical lymph node surgery (RLNS) in patients with locally advanced breast cancer classified as lymph node N3 disease according to the American Joint Committee on Cancer (AJCC) 2002 in whom there is no known distant metastasis and in the context of multimodal therapy. Patients and Methods: This was a two-Center retrospective study that included patients with breast cancer classified as N3M0 after (18)FDG-PET/CT assessment. We reviewed the clinical characteristics, surgical treatment and oncological outcomes of those patients. Results: Thirty-nine patients fulfilled the inclusion criteria. Multimodal treatment included neo-adjuvant chemotherapy (n=34), adjuvant radiotherapy (n=33), adjuvant chemotherapy (n=18) or neo- or adjuvant hormone therapy (n=17). Surgical treatment was not homogeneous. Eight patients had undergone RLNS and 31 conventional axillary lymph node dissection (CD). There was no significant difference in median overall survival between the RLNS group and the CD group (32 months (28-36) vs. 49 months (42-56) respectively (p=0.25)). The overall recurrence rate was 23%. Out of the 8 patients who had undergone RLNS, three had relapsed (two with distant metastases and one local). Conclusion: RLNS was not proven to be beneficial in our study. In order to guide surgical nzanagement for these patients, PET/CT and magnetic resonance imaging (MRI) could be of interest, therefore a pilot study to improve reproducible surgical management would be of interest.
机译：背景/目的：在F-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（（18）FDG-PET / CT）时代，越来越多的患者被诊断出患有N3M0疾病。这项研究的目的是根据2002年美国癌症联合委员会（AJCC）评估根治性淋巴结手术（RLNS）对局部晚期乳腺癌分类为淋巴结N3疾病的患者的预后影响。远处转移并采用多模式疗法。患者和方法：这是一项两中心回顾性研究，纳入经（18）FDG-PET / CT评估后归为N3M0的乳腺癌患者。我们回顾了这些患者的临床特征，手术治疗和肿瘤学结局。结果：39名患者符合纳入标准。多模式治疗包括新辅助化疗（n = 34），辅助放疗（n = 33），辅助化学疗法（n = 18）或新激素或辅助激素治疗（n = 17）。手术治疗不均匀。 8例患者接受了RLNS和31例常规腋窝淋巴结清扫术（CD）。 RLNS组和CD组之间的中位总生存期无显着差异（分别为32个月（28-36）和49个月（42-56）（p = 0.25））。总体复发率为23％。在接受RLNS治疗的8例患者中，有3例复发（2例有远处转移，1例局部复发）。结论：RLNS在我们的研究中没有被证明是有益的。为了指导这些患者的外科手术矫正，PET / CT和磁共振成像（MRI）可能是令人感兴趣的，因此，一项旨在改善可重复性外科治疗的初步研究将很重要。

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