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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Impact of Clinical Pharmacy Services in a Hematology/Oncology Inpatient Setting
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Impact of Clinical Pharmacy Services in a Hematology/Oncology Inpatient Setting

机译：临床药学服务对血液/肿瘤住院患者的影响

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Background/Aim: Clinical pharmacists are contributing to safe medication use by providing comprehensive management to patients and medical staff. However, little is known regarding their impact in oncology. The aim of this study was to document and evaluate the role of clinical pharmacy services in a hematology/oncology department. Patients and Methods: A prospective, descriptive, observational study was carried out from May 2012 to May 2013. Medication reviews concerning hospitalized adult cancer patients were performed twice a week. Medication problems, pharmaceutical interventions and acceptance rate by the oncologists were recorded by a clinical pharmacist. Results: A total of 4,393 prescriptions (including chemotherapy and support) of 489 adult cancer patients (mean age=63 years) were analyzed. The pharmacist identified 552 drug-related problems (12.6% of the prescriptions) primarily related to anti-infective agents (59.5%). Medication problems included inappropriate medications (20.6%), untreated indications (14.8%), inappropriate administrations (14.1%), underdosing (11.7%), drug-drug interactions (14.3%), lack of monitoring (9.6%), overdosing (8.9%), administration omissions (3.5%) and side-effects (2.5%). Interventions (n=552) led to treatment discontinuation (26.2%), drug dosing adjustments (21.5%), drug additions (16.9%), alternate routes of administration (11.7%), replacement of a drug by another one (10.7%), therapeutic drug monitoring (10.3%) and optimizing administration (2.6%). Most (96%) of the interventions were accepted and implemented by the medical staff. Conclusion: The integration of clinical pharmacy services resulted in drug-specific interventions in 12.6 % of the prescriptions of hospitalized adult patients with cancer. Medication problems mostly concerned anti-infective agents. The intervention acceptance rate by oncologists was high. The outcome of care in the hematology/oncology inpatient setting remains to be measured.
机译：背景/目的：临床药剂师通过为患者和医务人员提供全面管理，为安全用药做出了贡献。然而，关于它们在肿瘤学中的影响知之甚少。这项研究的目的是记录和评估血液/肿瘤科临床药学服务的作用。患者和方法：从2012年5月至2013年5月进行了一项前瞻性，描述性和观察性研究。每周两次对住院的成年癌症患者进行药物复查。临床药剂师记录了药物问题，药物干预和肿瘤学家的接受率。结果：共分析了489名成年癌症患者（平均年龄= 63岁）的4,393张处方（包括化疗和支持）。药剂师确定了552个与药物有关的问题（占处方的12.6％），主要与抗感染药有关（占59.5％）。药物问题包括不当用药（20.6％），未治疗的适应症（14.8％），不当用药（14.1％），用药不足（11.7％），药物间相互作用（14.3％），缺乏监控（9.6％），用药过量（8.9） ％），给药遗漏（3.5％）和副作用（2.5％）。干预（n = 552）导致治疗中断（26.2％），药物剂量调整（21.5％），药物添加（16.9％），其他给药途径（11.7％），另一种药物替代（10.7％） ，治疗药物监控（10.3％）和优化给药（2.6％）。大多数（96％）干预措施已被医务人员接受并实施。结论：临床药房服务的整合导致了针对住院的成人癌症患者处方的12.6％的针对药物的干预措施。药物问题主要涉及抗感染药。肿瘤科医生的干预接受率很高。血液/肿瘤科住院患者的护理结果尚待评估。

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