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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Significance of Histopathological Evaluation of Pancreatic Fibrosis to Predict Postoperative Course After Pancreatic Surgery
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Significance of Histopathological Evaluation of Pancreatic Fibrosis to Predict Postoperative Course After Pancreatic Surgery

机译：胰腺纤维化的组织病理学评估对预测胰腺手术后病程的意义

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Background/Aim: Pancreatic stellate cells (PSC) play a critical role in pancreatic fibrosis and the apparent diffusion coefficient (ADC) value based on the diffusion-weighted image (DWI) from magnetic resonance imaging (MRI) may he a predictor of tissue fibrosis. This study aimed to evaluate the pancreas texture from both histopathological and radiological viewpoints and to investigate the effect of pancreas texture on occurrence of postoperative pancreatic fistula (PF). Patients and Methods: We divided 40 patients into soft-pancreas group and hard-pancreas group, according to the histopathological evaluation of pancreatic fibrosis. We compared ADC values and occurrences of PF between the two groups. Results: Histopathological measurement lengths of interlobular and intralobular fibrosis increased significantly with the progression of fibrosis grade and PSC stage, while PSC stage correlated significantly with fibrosis grade (r=0.868, p<0.001). PF was detected in 14 out of 40 patients, including grade A in 7 patients and grade B/C in 7 patients. but there were no operative deaths. Pancreas texture (soft/hard), determined based on the combination of fibrosis grade and PSC stage, was 16/10 (no PF) and 14/0 (grade A/B/C PF) and the difference in the incidence was significant (p=0.022). Though ADC value was significantly lower in the hard-compared to the soft-pancreas group (1.48 +/- 0.42 vs. 1.73 +/- 0.27x10(-3) mm(2)/sec; p=0.033), there was no significant difference in ADC value between no PF versus grade A/B/C PF group. Conclusion: Histopathological evaluation of pancreas texture correlated negatively with ADC values and is critical to predict the occurrence of PF.
机译：背景/目的：胰腺星状细胞（PSC）在胰腺纤维化中起关键作用，基于磁共振成像（MRI）的弥散加权图像（DWI）的表观弥散系数（ADC）值可预测组织纤维化。本研究旨在从组织病理学和放射学角度评估胰腺质地，并研究胰腺质地对术后胰瘘（PF）发生的影响。患者和方法：根据胰腺纤维化的组织病理学评估，将40例患者分为软胰腺组和硬胰腺组。我们比较了两组之间的ADC值和PF的出现。结果：小叶间和小叶内纤维化的组织病理学测量长度随着纤维化等级和PSC分期的进展而显着增加，而PSC分期与纤维化等级显着相关（r = 0.868，p <0.001）。 40例患者中有14例检测到PF，其中A级7例，B / C级7例。但没有手术死亡。根据纤维化等级和PSC分期确定的胰腺质地（软/硬）分别为16/10（无PF）和14/0（A / B / C PF级），发生率差异显着（ p = 0.022）。尽管与硬胰腺组相比ADC值显着降低（1.48 +/- 0.42 vs. 1.73 +/- 0.27x10（-3）mm（2）/ sec; p = 0.033），但没有无PF与A / B / C级PF组之间ADC值的显着差异。结论：胰腺纹理的组织病理学评估与ADC值呈负相关，对于预测PF的发生至关重要。

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