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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Neutrophil-rich Gastric Carcinoma in the Integrated Cancer Registry of Eastern Sicily, Italy
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Neutrophil-rich Gastric Carcinoma in the Integrated Cancer Registry of Eastern Sicily, Italy

机译：意大利西西里岛东部综合癌症登记处中性粒细胞丰富的胃癌

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Background/Aim: Neutrophil-rich carcinoma is a variant of gastric carcinoma that has not been well-studied or characterized. The purpose of the present study was to reveal the incidence and clinicopathological findings compared to ordinary gastric carcinoma. Patients and Methods: A population-based series of 430 gastric cancers, identified between 2003 and 2006 from the province of Messina (insular Italy; population, 662,450), was used. The number of tumor-infiltrating neutrophils was assessed in a semi-quantitative manner using the mean value of 20 non-overlapping high-power fields (magnification, 400; 0.08 mm(2)). Tumors with >10 neutrophils per 20 high-power fields were arbitrarily considered as neutrophil-rich gastric carcinomas. Moreover, MUCI immunohistochemical expression was investigated to show possible correlation with neutrophil infiltration in gastric carcinomas. Results: Among 193 gastric cancers resected for curative purposes, 30 (15.54%) were represented by neutrophil-rich gastric carcinomas. These tumors occurred more frequently in patients aged more than 72 years (p<0.05), showing an inverse correlation with mucinous subtype according to the WHO classification (p<0.001) and expressed MUG1. However, intensity and distribution of MUC1 was heterogeneous, and independent of neutrophil infiltration within the tumor stroma. Conclusion: Neutrophil-rich carcinoma seems to represent a distinctive morphological variant of gastric carcinoma, although the true mechanism for the infiltration of neutrophils is still unclear.
机译：背景/目的：富含中性粒细胞癌是胃癌的一种变体，尚未得到充分研究或表征。本研究的目的是揭示与普通胃癌相比的发病率和临床病理结果。患者和方法：使用基于人群的一系列430例胃癌，该系列于2003年至2006年间从墨西拿（意大利中部;人口为662,450）鉴定。使用20个非重叠高倍视野的平均值（放大倍数为400; 0.08 mm（2））以半定量方式评估肿瘤浸润中性粒细胞的数量。每20个高倍视野中中性粒细胞> 10的肿瘤被任意认为是富含中性粒细胞的胃癌。此外，对MUCI免疫组织化学表达进行了研究，以显示与胃癌中性粒细胞浸润的可能相关性。结果：在切除的193例胃癌中，有30例（占15.54％）以中性粒细胞丰富的胃癌为代表。这些肿瘤在72岁以上的患者中更常见（p <0.05），根据WHO分类与粘液亚型呈负相关（p <0.001），并表达MUG1。然而，MUC1的强度和分布是异质的，并且独立于肿瘤基质内的中性粒细胞浸润。结论：尽管尚不清楚中性粒细胞浸润的真正机制，但富含中性粒细胞的癌似乎代表了胃癌的独特形态变异。

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