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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Proton Beam Therapy Combined with Concurrent Chemotherapy for Esophageal Cancer
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Proton Beam Therapy Combined with Concurrent Chemotherapy for Esophageal Cancer

机译：质子束疗法联合并行化疗治疗食管癌

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Background/Aim: The aim of the present study was to evaluate the outcomes of proton beam therapy (PBT) concurrently combined with chemotherapy consisting of cisplatin and 5-fluorouracil for esophageal cancer. Patients and Methods: Forty consecutive patients (stage I in 16 patients, II in 9 and III in 15) treated between 2008 and 2012 were evaluated. A total dose of 60 Gray equivalents (GyE) in 30 fractions was delivered, and an additional boost of 4-10 GyE was given when residual tumors were suspected. The median follow-up time was 24 months (range=7-66 months). Results: No cardio-pulmonary toxicities of grade 3 or higher were observed. Recurrences were observed in 16 patients, and the 2-year rates of disease-specific survival and locoregional control were 77% and 66%, respectively. Conclusion: Irrespective of the small sample size and short follow-up time of the study, proton beam therapy combined with chemotherapy seems to be feasible for esophageal cancer.
机译：背景/目的：本研究的目的是评估质子束治疗（PBT）与顺铂和5-氟尿嘧啶组成的化学疗法联合治疗食管癌的效果。患者和方法：对2008年至2012年间接受治疗的40例连续患者（I期16例，II期9例，III期15例）进行了评估。在30个部分中共递送了60格雷当量（GyE）的总剂量，当怀疑残留肿瘤时，可额外提高4-10 GyE。中位随访时间为24个月（范围= 7-66个月）。结果：未观察到3级或更高的心肺毒性。在16例患者中观察到复发，并且2年疾病特异性存活率和局部区域控制率分别为77％和66％。结论：无论研究的样本量少且随访时间短，质子束治疗与化学疗法联合治疗食管癌似乎都是可行的。

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