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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Detection of Bone Metastases Using C-11-Acetate PET in Patients with Prostate Cancer with Biochemical Recurrence
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Detection of Bone Metastases Using C-11-Acetate PET in Patients with Prostate Cancer with Biochemical Recurrence

机译：C-11-醋酸PET检测前列腺癌生化复发的骨转移

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摘要

Aim: To evaluate the diagnostic accuracy of C-11-acetate positron-emission tomography (PET) in the detection of bone metastasis in patients with prostate cancer with biochemical recurrence. Patients and Methods: Ninety patients (100%) with rising prostate-specific antigen (PSA) levels (>0.2 ng/ml) after radical prostatectomy, who had both C-11-acetate PET and bone scan performed and who had clinical follow-up/imaging follow-up for bone metastasis, considered a gold standard, were included. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for C-11-acetate PET were calculated on a per-patient basis. Results: C-11-Acetate PET and Tc-99m-dicarboxypropane-diphosphonate findings were concordant in 84 (93.3%) patients [35 (38.9%) true-positive, 49 (54.4%) true-negative]. Discordant findings were observed in six patients (6.7%). C-11-Acetate PET presented two (2.2%) false-positive and four (4.4%) false-negative findings. The sensitivity, specificity, PPV, and NPV for C-11-acetate PET were 89.7%, 96.1%, 94.6%, and 92.2%, respectively. The median PSA of patients with multiple skeletal metastases (median=23.64 ng/ml, range=3.16-551.1 ng/ml) differed significantly (p=0.018) from that of patients with focal metastases (median=6.7 ng/ml, range=0.31-12.8 ng/ml). Conclusion: C-11-Acetate PET is a useful tool for patients with prostate cancer with biochemical recurrence, as it can depict multiple sites of recurrence and in particularly shows a high diagnostic value equivalent to that of bone scan for the detection of bone metastases.
机译：目的：评估C-11-乙酸正电子发射断层扫描（PET）在生化复发前列腺癌患者中检测骨转移的诊断准确性。患者和方法：90例（100％）前列腺癌根治术后患者的前列腺特异性抗原（PSA）水平升高（> 0.2 ng / ml），同时进行了C-11-醋酸PET和骨扫描，并进行了临床随访-包括了金标准的骨转移的随访/影像学随访。每位患者计算C-11-乙酸酯PET的敏感性，特异性，阳性预测值（PPV）和阴性预测值（NPV）。结果：C-11-醋酸酯PET和Tc-99m-二羧基丙烷-二膦酸酯的发现在84例（93.3％）患者中相符[35例（38.9％）为真阳性，49例（54.4％）为真阴性]。在六名患者（6.7％）中观察到不一致的发现。 C-11-醋酸PET显示两个假阳性结果（2.2％）和四个假阴性结果（4.4％）。 C-11-乙酸酯PET的敏感性，特异性，PPV和NPV分别为89.7％，96.1％，94.6％和92.2％。多发性骨转移患者（中位数= 23.64 ng / ml，范围= 3.16-551.1 ng / ml）的中位PSA与局灶性转移患者（中位数= 6.7 ng / ml，范围= 0.31-12.8 ng / ml）。结论：C-11-Acetate PET对生化复发的前列腺癌患者是一种有用的工具，因为它可以描绘多个复发部位，并且特别显示出与骨扫描相同的高诊断价值，可用于检测骨转移。

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