...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Elimination of Ras Suppressor-1 from Hepatocellular Carcinoma Cells Hinders their In Vitro Metastatic Properties
【24h】

Elimination of Ras Suppressor-1 from Hepatocellular Carcinoma Cells Hinders their In Vitro Metastatic Properties

机译：从肝癌细胞中消除Ras Suppressor-1阻碍了其体外转移特性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aim: Extracellular matrix (ECM) is of great significance for homeostasis in the liver. In fact, one of the stags leading to hepatocellular carcinoma (HCC) includes accumulation of excess ECM. Ras Suppressor-1 (RSU-1) is localized in the cell-ECM adhesions but its role in HCC is unexplored. Materials and Methods: We investigated the expression and role of RSU-1 in two HCC cell lines that differ in aggressiveness; non-invasive Alexander cells and highly invasive HepG2 cells. Results: Our results showed that RSU-1 expression is elevated in HepG2 cells both at the mRNA and protein level, while its silencing leads to increased cell proliferation in both cell lines. Interestingly, RSU-1 depletion from highly invasive HepG2 cells reduces cell adhesion and invasion. Conclusion: This is the first study to provide in vitro evidence for the involvement of RSU-1 in HCC cell invasive behavior.
机译：背景/目的：细胞外基质（ECM）对于肝脏的体内平衡具有重要意义。实际上，导致肝细胞癌（HCC）的雄鹿之一包括多余的ECM的积累。 Ras Suppressor-1（RSU-1）定位于细胞ECM粘附中，但尚未探讨其在HCC中的作用。材料和方法：我们研究了RSU-1在两种侵袭性不同的HCC细胞系中的表达和作用。非侵入性亚历山大细胞和高度侵入性HepG2细胞。结果：我们的结果表明，RSU-1在HepG2细胞中的mRNA和蛋白水平均升高，而其沉默导致两种细胞系中细胞增殖的增加。有趣的是，高侵袭性HepG2细胞的RSU-1消耗减少了细胞粘附和侵袭。结论：这是第一个为RSU-1参与HCC细胞侵袭行为提供体外证据的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号