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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Female Genital Tract Chronic Graft-versus-Host Disease: Review of the Literature
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Female Genital Tract Chronic Graft-versus-Host Disease: Review of the Literature

机译：女性生殖道慢性移植物抗宿主病：文献综述

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Background: Chronic graft-versus-host disease (cGVHD) is the most common late complication of allogeneic hernatopoietic stem cell transplantation (allo-HSCT). Although the involvement of skin, oral cavity, eyes, liver and gut is well-described, gynaecological manifestations are rare, often undiagnosed and untreated. Materials and Methods: A selective literature search of articles in English language, published from 1982 to 2014 (indexed in PubMed) was performed. Discussion: Genital cGVHD is characterised by polymorphic clinical manifestations with sclerotic changes of the vulva and vagina. Introital stenosis or complete vaginal closure were reported in severe cases. Thus, cGVHD can seriously affect female sexual function and the overall quality of life. A prompt diagnosis and an appropriate therapy may prevent the development of severe forms and the need for surgery. Thus, a systematic specialized gynaecological consultation should be performed early in every allo-HSCT recipient as part of the routine post-transplantation management, even in asymptomatic women.
机译：背景：慢性移植物抗宿主病（cGVHD）是同种异体造血干细胞移植（allo-HSCT）最常见的晚期并发症。尽管皮肤，口腔，眼睛，肝脏和肠道受累的描述很清楚，但妇科表现很少见，常常未经诊断和治疗。材料和方法：进行了1982年至2014年出版的英语文章的选择性文献检索（在PubMed中检索）。讨论：生殖器cGVHD的特征是多形的临床表现，外阴和阴道硬化。在严重的病例中报告有口狭窄或完全的阴道闭合。因此，cGVHD会严重影响女性的性功能和整体生活质量。及时的诊断和适当的治疗可能会阻止严重形式的发展和手术需求。因此，作为常规的移植后管理措施，即使是无症状的女性，也应尽早在每位同种异体造血干细胞移植接受者中进行系统的专业妇科咨询。

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