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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >MicroRNA-503 Promotes Tumor Progression and Acts as a Novel Biomarker for Prognosis in Oesophageal Cancer
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MicroRNA-503 Promotes Tumor Progression and Acts as a Novel Biomarker for Prognosis in Oesophageal Cancer

机译：MicroRNA-503促进肿瘤进展并充当食管癌预后的新型生物标志物

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Aim: This study investigated microRNA (miR)-503 expression levels and evaluated its clinical significance in patients with oesophageal cancer (EC). Materials and Methods: miR-503 expression was quantified by quantitative reverse transcription-polymerase chain reaction in 49 EC tissue samples and 12 adjacent normal tissues from 49 patients with EC. The association between miR-503 expression and clinicopathological factors, including prognostic outcomes, were assessed. Results: miR-503 was found up-regulated in EC tissues compared to adjacent normal tissues. High miR-503 expression was significantly associated with large tumor size. Kaplan-Meier analysis showed that patients with high miR-503 expression had significantly poorer disease-free and overall survival than those with lower expression levels. High miR-503 expression was identified as an independent prognostic predictor in patients with EC according to multivariate analysis. Conclusion: miR-503 expression affects tumor cell proliferation in EC. Evaluation of miR-503 expression might thus help identify patients with EC with poor prognosis and higher risk of early recurrence.
机译：目的：本研究调查了microRNA（miR）-503的表达水平，并评估了其在食道癌（EC）患者中的临床意义。材料与方法：通过定量逆转录-聚合酶链反应在49例EC患者的49例EC组织样品和12例邻近正常组织中定量miR-503的表达。评估了miR-503表达与临床病理因素（包括预后）之间的关联。结果：与相邻的正常组织相比，在EC组织中发现了miR-503上调。高miR-503表达与大肿瘤显着相关。 Kaplan-Meier分析表明，与那些表达水平较低的患者相比，miR-503表达较高的患者的无病生存期和总生存期明显较差。根据多变量分析，miR-503高表达被确定为EC患者的独立预后指标。结论：miR-503的表达影响了EC中肿瘤细胞的增殖。因此，评估miR-503的表达可能有助于鉴定预后较差，早期复发风险较高的EC患者。

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