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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Predominance of Th17 Over Regulatory T-Cells in Pleural Effusions of Patients with Lung Cancer Implicates A Proinflammatory Profile
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Predominance of Th17 Over Regulatory T-Cells in Pleural Effusions of Patients with Lung Cancer Implicates A Proinflammatory Profile

机译：肺癌患者胸腔积液中Th17在调节性T细胞中占主导地位暗示了炎性反应

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Background: Regulatory T- (Treg) and proinflammatory T-helper 17 (Th17) cells have been reported to be involved in the pathogenesis of pleural effusions caused by lung cancer. However, the presence of these subsets might not be a consequence of tumor pathogenesis, but rather a result of the pleural effusion itself irrespective of its origin. In the present study, we analyzed the balance between these CD4+ T-cell subsets and compared them with those in non-malignant pleural effusions. Patients and Methods: We detected the frequencies of Treg and Th17 cells, identified as cluster of differentiation (CD)3(+)CD4(+)CD25(+)CD127(low/-) and CD3(+)CD4(+) retinoid-related orphan receptor gamma t (ROR gamma t)+ cells respectively, and proportions of interleukin (IL)17A-producing CD4(+) cells in pleural effusions of patients with lung cancer, tuberculous and non-chronic pathologies by flow cytometry. The cytokine profile of stimulated CD4(+) T-cells from tuberculosis and cancer groups was compared. Results: The proportion of Th17 cells were increased whereas Tregs were decreased in both tuberculosis and cancer, but not in non-chronic pathologies. Nevertheless, CD4(+) T-cells from lung cancer effusions secreted interferon (IFN)gamma, IL6 and IL17A, whereas CD4(+) T-cells from tuberculous effusions secreted IL10 and low levels of IFN gamma. Conclusion: Although effusions from patients with chronic pathologies presented higher proportions of Th17 cells in comparison to those with non-chronic pathologies, only Th17 cells from malignant effusions maintained their proinflammatory profile after stimulation.
机译：背景：据报道，调节性T-（Treg）和促炎性T-辅助17（Th17）细胞与肺癌引起的胸腔积液的发病机制有关。但是，这些亚群的存在可能不是肿瘤发病机制的结果，而是胸膜腔积液本身的结果，无论其起源如何。在本研究中，我们分析了这些CD4 + T细胞亚群之间的平衡，并将其与非恶性胸腔积液中的那些进行了比较。患者和方法：我们检测了Treg和Th17细胞的频率，被鉴定为分化簇（CD）3（+）CD4（+）CD25（+）CD127（low /-）和CD3（+）CD4（+）类视黄醇流式细胞术检测肺癌，结核病和非慢性病患者胸腔积液中的相关孤儿受体γt（ROR gamma t）+细胞，以及产生白介素（IL）17A的CD4（+）细胞的比例。比较了来自结核病和癌症组的受激CD4（+）T细胞的细胞因子概况。结果：在结核病和癌症中，Th17细胞的比例增加，而Tregs则减少，但在非慢性病中则没有。但是，肺癌积液中的CD4（+）T细胞分泌干扰素（IFN）γ，IL6和IL17A，而结核积液中的CD4（+）T细胞则分泌IL10和低水平的IFNγ。结论：尽管慢性病患者的积液与非慢性病患者的Th17细胞比例较高，但只有恶性积液的Th17细胞在刺激后仍保持其促炎特性。

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