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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Pre-treatment Neutrophil to Lymphocyte Ratio Is a Predictor of Prognosis in Endometrial Cancer
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Pre-treatment Neutrophil to Lymphocyte Ratio Is a Predictor of Prognosis in Endometrial Cancer

机译：嗜中性粒细胞与淋巴细胞比例的预处理是子宫内膜癌预后的预测指标

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Background/Aim: Inflammation and tumor immunology are important in the prognosis of various cancers. We herein investigated whether pre-treatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and serum cancer antigen 125 (CAl25) predict recurrence and survival in patients with endometrial cancer (EC). Patients and Methods: We collected complete blood counts and clinicopathological data from medical records of 320 patients with EC; their pre-treatment NLR, PLR and CAl25 were analyzed for correlations with recurrence and survival, retrospectively. Results: Disease-free survival (DFS) and overall survival (OS) rates of patients with high NLR and CAl25 were significantly shorter than those for patients with low NLR and CAl25 (DFS: p=0.002 and p<0.001; OS: p<0.001 and p<0.001, respectively). Furthermore, NLR was also an independent predictive factor for mortality in multivariate analysis (hazard ratio (HR)=3.318; 95% confidence interval (CI). 1.154-9.538; p=0.026). Conclusion: Pre-treatment NLR is a predictor of poor prognosis in EC.
机译：背景/目的：炎症和肿瘤免疫学在各种癌症的预后中很重要。我们在此调查了治疗前的中性粒细胞与淋巴细胞比率（NLR），血小板与淋巴细胞比率（PLR）和血清癌抗原125（CAl25）是否可预测子宫内膜癌（EC）患者的复发和生存。患者和方法：我们从320例EC患者的病历中收集了全血细胞计数和临床病理数据。回顾性分析他们的治疗前NLR，PLR和CAl25与复发和生存的相关性。结果：高NLR和CAl25的患者的无病生存（DFS）和总体生存（OS）的比率显着低于低NLR和CAl25的患者（DFS：p = 0.002和p​​ <0.001; OS：p <分别为0.001和p <0.001）。此外，在多变量分析中，NLR还是死亡率的独立预测因素（危险比（HR）= 3.318; 95％置信区间（CI）.1.154-9.538; p = 0.026）。结论：治疗前NLR可预示EC预后不良。

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