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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >MicroRNA Expression in Differentially Metastasizing Tumors of the Head and Neck: Adenoid Cystic Versus Squamous Cell Carcinoma
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MicroRNA Expression in Differentially Metastasizing Tumors of the Head and Neck: Adenoid Cystic Versus Squamous Cell Carcinoma

机译：头颈部差异转移性肿瘤中的MicroRNA表达：腺样囊性对鳞状细胞癌。

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Background/Aim: Head and neck adenoid cystic carcinoma (HNACC) is a rare malignancy of the salivary glands with a tendency to metastasize in lung or liver without lymph node involvement, whereas squamous cell carcinoma (HNSCC) preferentially metastasizes to locoregional lymph nodes. The expression patterns of microRNA, a class of small non-coding RNA transcripts, involved in gene regulation and various developmental processes, could he of influence during the metastatic process. The aim of the present study was to compare mircoRNA expression patterns of HNACC and HNSCC. Materials and Methods: In a total of 21 tissue samples, a genome-wide screening for microRNAs was performed. A microRNA array platform was used for the identification of target microRNA. Results: Five microRNAs, hsa-MiR-214, hsa-MiR-125a-5p, hsa-MiR-574-3p, hsa-MiR-199a-3p/199b-3p and hsa-miR-199a-5p were identified to be over-expressed in HNACC compared to HNSCC, whereas hsa-MiR-452 showed a lower expression level. Conclusion: Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior.
机译：背景/目的：头颈部腺样囊性癌（HNACC）是唾液腺的一种罕见恶性肿瘤，在不涉及淋巴结的情况下有在肺或肝中转移的趋势，而鳞状细胞癌（HNSCC）优先转移到局部淋巴结。 microRNA的表达模式是一类小的非编码RNA转录物，参与基因调控和各种发育过程，可能在转移过程中产生影响。本研究的目的是比较HNACC和HNSCC的mircoRNA表达模式。材料和方法：在总共21个组织样本中，进行了全基因组筛选microRNA。 microRNA阵列平台用于鉴定目标microRNA。结果：鉴定出五个微RNA，分别是hsa-MiR-214，hsa-MiR-125a-5p，hsa-MiR-574-3p，hsa-MiR-199a-3p / 199b-3p和hsa-miR-199a-5p。与HNSCC相比，HNACC中过表达，而hsa-MiR-452显示较低的表达水平。结论：我们的数据显示，mircoRNA在HNACC和HNSCC中的表达模式明显不同，这支持了肿瘤特异性表达的理论，并为不同的临床行为提供了提示。

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