Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate

Pérez-LlarenaF.J.; FernándezA.; ZamoranoL.; KerffF.; BeceiroA.; AracilB.; CercenadoE.; MiroE.; OliverA.; OteoJ.; NavarroF.; BouG.

首页> 外文期刊>Antimicrobial agents and chemotherapy. >Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate

【24h】

Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate

机译：西班牙产产克雷伯菌的新型IMP-28金属β-内酰胺酶的特征

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

An isolate of Klebsiella oxytoca carrying a novel IMP metallo-β- lactamase was discovered in Madrid, Spain. The bla IMP-28 gene is part of a chromosomally located class I integron. The IMP-28 k cat/K m values for ampicillin, ceftazidime, and cefepime and, to a lesser extent, imipenem and meropenem, are clearly lower than those of IMP-1. The His306Gln mutation may induce important modifications of the L3 loop and thus of substrate accessibility and hydrolysis and be the main reason for this behavior.

机译：在西班牙马德里发现了一种携带新型IMP金属-β-内酰胺酶的产酸克雷伯菌的分离株。 bla IMP-28基因是位于染色体上的I类整合子的一部分。氨苄青霉素，头孢他啶和头孢吡肟的IMP-28 k cat / K m值，以及亚胺培南和美洛培南（在较小程度上）明显低于IMP-1。 His306Gln突变可能会诱导L3环的重要修饰，从而导致底物可及性和水解，并且是造成此现象的主要原因。

著录项

来源
《Antimicrobial agents and chemotherapy.》 |2012年第8期|共4页
作者
Pérez-LlarenaF.J.; FernándezA.; ZamoranoL.; KerffF.; BeceiroA.; AracilB.; CercenadoE.; MiroE.; OliverA.; OteoJ.; NavarroF.; BouG.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate [J] . Pérez-LlarenaF.J., FernándezA., ZamoranoL., Antimicrobial agents and chemotherapy. . 2012,第8期

机译：西班牙产产克雷伯菌的新型IMP-28金属β-内酰胺酶的特征
2. Molecular characterization of TEM-59 (IRT-17), a novel inhibitor-resistant TEM-derived beta-lactamase in a clinical isolate of Klebsiella oxytoca. [J] . Bermudes H, Jude F, Chaibi EB, Antimicrobial agents and chemotherapy. . 1999,第7期

机译：TEM-59（IRT-17）的分子表征，一种在临床分离的产酸克雷伯菌中具有抗抑制剂作用的新型TEMβ-内酰胺酶。
3. Evaluation of the Clinical and Laboratory Standards Institute phenotypic confirmatory test to detect the presence of extended-spectrum β-lactamases from 4005 Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis isolates [J] . Ian Morrissey, Samuel K. Bouchillon, Meredith Hackel, Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland . 2014,第4期

机译：对临床和实验室标准协会表型确认试验的评估，以检测来自4005大肠杆菌，产酸克雷伯菌，肺炎克雷伯菌和奇异变形杆菌分离株的广谱β-内酰胺酶
4. Comparison of capacity for 2, 3-Butanediol production from corn cob hemicelluose hydrolysate fermentation by Klebsiella oxytoca HD79 and Klebsiella pneumoniae [C] . Jing-Ping Ge, Shou-Feng Huang, Xing-Lin Li, International Conference on Renewable Energy and Environmental Technology . 2014

机译：从玉米蟹o玉米菌玉米菌玉米蛋白玉米菌水解发酵的2,3-丁二醇产量的能力比较HD79和Klebsiella Pneumoniae
5. Studies on characterization of polysaccharide from Klebsiella oxytoca and enzymatic modification of selected polysaccharides [D] . Cui, Weidong 1996

机译：产酸克雷伯菌的多糖表征及部分多糖的酶促修饰研究
6. Characterization of a Novel IMP-28 Metallo-β-Lactamase from a Spanish Klebsiella oxytoca Clinical Isolate [O] . Francisco José Pérez-Llarena, Ana Fernández, Laura Zamorano, 2012

机译：从西班牙产克雷伯菌临床分离株中新型的IMP-28Metallo-β-内酰胺酶的表征
7. Characterization of a Novel IMP-28 Metallo-β-Lactamase from a Spanish Klebsiella oxytoca Clinical Isolate [O] . Francisco José Pérez-Llarena, Ana Fernández, Laura Zamorano, 2012

机译：来自西班牙Klebsiella ocktoca临床分离物的新型IMP-28 Metallo-β-内酰胺酶的表征

Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate

摘要

著录项

相似文献

相关主题

期刊订阅