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In vitro activities of antifungal combinations against biofilms and planktonic forms of clinical Trichosporon asahii isolates

机译:抗真菌组合物对临床Trichosporon asahii分离株的生物膜和浮游形式的体外活性

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摘要

Trichosporon species can cause biofilm-associated infections related to indwelling medical devices, especially intravenous catheters, and unacceptable mortality rates have been reported despite the administration of antifungal treatments (1). Tricho-sporon asahii can form biofilms with structured microbial communities in vitro, embedded within an extracellular matrix, with significantly increased resistance to antifungal compounds (2, 3), which might ultimately lead to clinical treatment failure. Antifungal combination maybe an alternative therapy strategy for biofilm-related fungal infections (4). The synergistic effects of antifungal combinations against other fungal biofilms have been detected in vitro, such as amphotericin B-posaconazole for Candida albicans (5) and amphotericin B-caspofungin or vori-conazole-caspofungin for Aspergillus spp. (6).
机译:天花粉菌可能引起与生物膜相关的感染,这些感染与留置医疗设备(尤其是静脉内导管)有关,尽管进行了抗真菌治疗,但仍有报道称死亡率不可接受(1)。 Tricho-sporon asahii可以在体外形成具有结构化微生物群落的生物膜,包埋在细胞外基质中,对抗真菌化合物的抵抗力显着提高(2、3),这可能最终导致临床治疗失败。抗真菌药物联合治疗可能是生物膜相关真菌感染的另一种治疗策略(4)。体外已检测到抗真菌剂对其他真菌生物膜的协同作用,例如两性霉素B-posaconazole用于白色念珠菌(5),两性霉素B-caspofungin或两性康康唑-caspofungin用于曲霉菌。 (6)。

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