New insights into the in vitro susceptibility of Pythium insidiosum

Loretoé.S.; TondoloJ.S.M.; PilottoM.B.; AlvesS.H.; SanturioaJ.M.

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New insights into the in vitro susceptibility of Pythium insidiosum

机译：腐霉菌体外敏感性的新见解

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We have determined the in vitro activity of several antibacterial and antifungal drugs against Pythium insidiosum using broth microdilution (BMD), disk diffusion, and Etest methods. The largest zones of inhibition (disk diffusion) and the lowest BMD and Etest MICs were observed for azithromycin, clarithromycin, linezolid, mupirocin, doxycycline, minocycline, and tigecycline. The in vitro activities observed suggest that antibacterials, which act by inhibiting protein synthesis, are promising candidate therapies for the treatment of pythiosis.

机译：我们已经通过肉汤微稀释（BMD），圆盘扩散和Etest方法确定了几种抗菌和抗真菌药物对腐霉病的体外活性。对于阿奇霉素，克拉霉素，利奈唑胺，莫匹罗星，强力霉素，米诺环素和替加环素，观察到最大的抑制区（盘扩散）和最低的BMD和Etest MIC。所观察到的体外活性表明，通过抑制蛋白质合成起作用的抗菌剂是用于治疗烟毒症的有前途的候选疗法。

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《Antimicrobial agents and chemotherapy.》 |2014年第12期|共4页
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Loretoé.S.; TondoloJ.S.M.; PilottoM.B.; AlvesS.H.; SanturioaJ.M.;
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New insights into the in vitro susceptibility of Pythium insidiosum

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