Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits candida albicans and staphylococcus aureus biofilm formation in vivo

DeCremerK.; DelattinN.; DeBruckerK.; PeetersA.; KucharíkováS.; GeritsdE.; VerstraetenA.N.; MichielsJ.; VanDijckP.; CammueB.P.A.; ThevissenaK.

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Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits candida albicans and staphylococcus aureus biofilm formation in vivo

机译：口服广谱抗生物膜化合物托瑞米芬在体内抑制白色念珠菌和金黄色葡萄球菌生物膜形成

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We here report on the in vitro activity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, including Candida albicans, Candida glabrata, Candida dubliniensis, Candida krusei, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. We validated the in vivo efficacy of orally administered toremifene against C. albicans and S. aureus biofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.

机译：我们在这里报告了托瑞米芬在体外抑制不同真菌和细菌病原体的生物膜形成的活性，其中包括白色念珠菌，光滑念珠菌，dubliniensis念珠菌，克鲁斯念珠菌，铜绿假单胞菌，金黄色葡萄球菌和表皮葡萄球菌。我们在大鼠皮下导管模型中验证了口服托瑞米芬对白色念珠菌和金黄色葡萄球菌生物膜形成的体内功效。综合来看，我们的结果证明了托瑞米芬作为广谱口服抗生物膜化合物的潜力。

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《Antimicrobial agents and chemotherapy.》 |2014年第12期|共5页
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DeCremerK.; DelattinN.; DeBruckerK.; PeetersA.; KucharíkováS.; GeritsdE.; VerstraetenA.N.; MichielsJ.; VanDijckP.; CammueB.P.A.; ThevissenaK.;
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1. Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits candida albicans and staphylococcus aureus biofilm formation in vivo [J] . DeCremerK., DelattinN., DeBruckerK., Antimicrobial agents and chemotherapy. . 2014,第12期

机译：口服广谱抗生物膜化合物托瑞米芬在体内抑制白色念珠菌和金黄色葡萄球菌生物膜形成
2. Antibiofilm efficacy of curcumin in combination with 2-aminobenzimidazole against single- and mixed-species biofilms of Candida albicans and Staphylococcus aureus [J] . Tan Yulong, Leonhard Matthias, Moser Doris, Colloids and Surfaces, B. Biointerfaces . 2019,第期

机译：姜黄素与2-氨基双咪唑组合对抗念珠菌念珠菌和金黄色葡萄球菌的单氨基双咪唑的疗效
3. Biofilm formation by Candida albicans and Staphylococcus aureus [J] . Yang L., Chen D. Q. Basic & clinical pharmacology & toxicology. . 2019,第S8期

机译：Biofilm Candida albicans和金黄色葡萄球菌的形成
4. In vitro evaluation of Candida albicans biofilm formation on denture base PMMA resin incorporated with silver nanoparticles and its effect on flexural strength [C] . Sahana Bajracharya, Sroisiri Thaweboon, Boonyanit Thaweboon International Conference on Applied Materials and Electronics Engineering . 2014

机译：念珠菌对牙本质基础PMMA树脂的念珠菌蛋白质形成生物膜形成的体外评价及其对弯曲强度的影响
5. Properties of silver and copper nanoparticle-containing aqueous solutions and evaluation of their in vitro activity against Candida albicans and Staphylococcus aureus biofilms [D] . Montes Aguirre, Melissa Mariluz 2015

机译：含银和铜纳米粒子的水溶液的性质及其对白色念珠菌和金黄色葡萄球菌生物膜的体外活性评估
6. Oral Administration of the Broad-Spectrum Antibiofilm Compound Toremifene Inhibits Candida albicans and Staphylococcus aureus Biofilm Formation In Vivo [O] . Kaat De Cremer, Nicolas Delattin, Katrijn De Brucker, 2014

机译：口服广谱抗生物膜化合物托瑞米芬抑制白色念珠菌和金黄色葡萄球菌体内生物膜形成。
7. Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in vivo [O] . De Cremer Kaat, Delattin Nicolas, De Brucker Katrijn, 2014

机译：口服广谱抗生物膜化合物托瑞米芬在体内抑制白色念珠菌和金黄色葡萄球菌生物膜形成

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Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits candida albicans and staphylococcus aureus biofilm formation in vivo

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