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首页> 外文期刊>Applied optics >Near-infrared laser tomographic imaging with right-angled scattered coherent light using an optical heterodyne-detection-based confocal scanning system
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Near-infrared laser tomographic imaging with right-angled scattered coherent light using an optical heterodyne-detection-based confocal scanning system

机译：使用基于光学外差检测的共聚焦扫描系统使用直角散射相干光进行近红外激光层析成像

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摘要

We demonstrate, what is to the best of our knowledge, a novel optical tomographic method for the visualization of the inner structure of scattering media such as biological tissue in the near-infrared region. We constructed a scanning confocal imaging system with a cross-axes arrangement using optical fibers. This system is based on the optical heterodyne technique and enables the detection of very weak coherence photons that are generated in the spatially restricted confocal region and scattered laterally (90 deg) against an incident beam. To evaluate the fundamental imaging capabilities of the system, we assessed measurements from scattering phantoms composed of an Intralipid suspension with varying volume concentrations. The results of this study demonstrate that the right-angled scattered light adheres to the Lambert-Beer law and that the present system can detect light propagating through a distance of approx31l of the mean free path. An inclusion as small as 100 (mu)m can be discriminated in a scattering media with an optical thickness of 4. We investigated the potential of the proposed system for imaging biological tissues in preliminary experiments using samples of chicken breast tissue.
机译：我们尽我们所知展示了一种新颖的光学层析成像方法，用于可视化散射介质（例如在近红外区域中的生物组织）的内部结构。我们使用光纤构造了具有交叉轴排列的扫描共聚焦成像系统。该系统基于光学外差技术，能够检测非常弱的相干光子，这些光子是在空间受限的共聚焦区域中产生的，并且相对于入射光束横向散射（90度）。为了评估系统的基本成像功能，我们评估了由体积浓度不同的脂质体悬浮液组成的散射体模的测量结果。这项研究的结果表明，直角散射光符合朗伯-比尔定律，并且本系统可以检测通过平均自由程约31l的距离传播的光。可以在光学厚度为4的散射介质中分辨出小至100μm的夹杂物。我们在初步实验中使用鸡胸组织样品对提出的生物组织成像系统进行了研究。

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