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Side-polished multimode fiber biosensor based on surface plasmon resonance with halogen light

机译：基于表面等离子体共振与卤素光的侧抛光多模光纤生物传感器

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摘要

A side-polished multimode fiber sensor based on surface plasmon resonance (SPR) as the transducing element with a halogen light source is proposed. The SPR fiber sensor is side polished until half the core is closed and coated with a 37 nm gold thin film by dc sputtering. The SPR curve on the optical spectrum is described by an optical spectrum analyzer and can sense a range of widths in wavelengths of SPR effects. The measurement system using the halogen light source is constructed for several real-time detections that are carried out for the measurement of the index liquid detections for the sensitivity analysis. The sensing fiber is demonstrated with a series of refractive index (RI) liquids and set for several experiments, including the stability, repeatability, and resolution calibration. The results for the halogen light source with the resolution of the measurement based on wavelength interrogation were 3 X 10~(-6) refractive index units (RIUs). The SPR dip shifted in wavelength is used as a measure of the RI change at a surface, and this RI change varies directly with the number of biomolecules at the surface. The SPR dip shift in wavelength, which was hybridized at 0.1 (mu)M of the target DNA to the probe DNA, was 8.66 nm. The all-fiber multimode SPR sensor, which has the advantages of being low cost, being disposable, having high stability and linearity, being free of labeling, and having potential for real-time detection, permit the sensor and system to be used in biochemical sensing and environmental monitoring.
机译：提出了一种基于表面等离振子共振（SPR）的侧面抛光多模光纤传感器，该传感器为卤素光源。对SPR光纤传感器进行侧面抛光，直到芯线的一半闭合为止，并通过直流溅射涂上37 nm的金薄膜。光谱上的SPR曲线由光谱分析仪描述，可以感应SPR效应的波长范围内的宽度。使用卤素光源的测量系统可用于多个实时检测，这些实时检测用于测量用于敏感度分析的指示液检测。感应光纤通过一系列折射率（RI）液体进行演示，并设置用于多个实验，包括稳定性，可重复性和分辨率校准。卤素光源的测量分辨率基于波长询问，结果为3 X 10〜（-6）折射率单位（RIU）。波长上移动的SPR倾角用作表面RI变化的量度，并且此RI变化直接随表面生物分子的数量而变化。在0.1μM的靶DNA与探针DNA上杂交的SPR的波长倾斜位移为8.66nm。全光纤多模SPR传感器具有成本低，可抛弃，具有高稳定性和线性度，无标签且具有实时检测的潜力的优点，允许该传感器和系统用于生化中传感和环境监测。

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