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Dynamic schema for near infrared detection of pressure-induced changes in solid tumors

机译：用于实体瘤压力诱发变化的近红外检测的动态方案

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摘要

Differentiation among malignant tumors, benign tumors, and normal tissue is highly important in the diagnosis and treatment of many malignancies. We have proposed a dynamic schema for noninvasive characterization of pressure-induced changes in solid tumors. Our hypothesis has been that the altered neovascularization processes within cancer-bearing tissues may significantly increase vascular resistance and cause a much slower response of hemoglobin concentration during a dynamic compression stimulus. This hypothesis was tested by the evaluation of data generated from human tumor clinical testing and from animal tumor model testing. In the human tumor clinical testing, a unified diagnostic criterion was derived that integrated the relative characteristics of tumor oxygen, hemoglobin, and hemoglobin dynamics. By applying such a unified criterion, we were able to differentiate benign breast lesions and malignant breast tumors with high sensitivity and specificity within a subset of 14 suspicious breast lesions with similar size and depth characteristics. In the animal testing, a stepped compression load was applied to the subcutaneous tumor deposit on an athymic NU/NU nude mouse model with subcutaneous xenograft BxPC-3 cancer. Characteristic differences were observed between the premortem tumor and the postmortem tumor in terms of pressure-induced tumor structural and functional changes.
机译：恶性肿瘤，良性肿瘤和正常组织之间的区分在许多恶性肿瘤的诊断和治疗中非常重要。我们已经提出了一种动态模式，用于非侵入性表征实体瘤中压力引起的变化。我们的假设是，在动态压缩刺激过程中，患癌组织内新血管形成过程的改变可能会显着增加血管阻力，并导致血红蛋白浓度的响应变慢。通过评估从人类肿瘤临床测试和动物肿瘤模型测试生成的数据来检验该假设。在人类肿瘤临床测试中，得出了统一的诊断标准，该标准整合了肿瘤氧，血红蛋白和血红蛋白动力学的相对特征。通过采用这种统一的标准，我们能够在14个大小和深度特征相似的可疑乳腺病变的子集中，以高灵敏度和特异性区分良性乳腺病变和恶性乳腺肿瘤。在动物实验中，在具有皮下异种移植BxPC-3癌症的无胸腺NU / NU裸鼠模型上，对皮下肿瘤沉积物施加了阶梯式压缩负荷。就压力引起的肿瘤结构和功能变化而言，在死前肿瘤和死后肿瘤之间观察到特征差异。

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