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首页> 外文期刊>Applied optics >Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance
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Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance

机译：通过光谱漫反射快速准确地估计血液饱和度，黑色素含量和表皮厚度

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摘要

We present a method to determine chromophore concentrations, blood saturation, and epidermal thickness of human skin from diffuse reflectance spectra. Human skin was approximated as a plane-parallel slab of variable thickness supported by a semi-infinite layer corresponding to the epidermis and dermis, respectively. The absorption coefficient was modeled as a function of melanin content for the epidermis and blood content and oxygen saturation for the dermis. The scattering coefficient and refractive index of each layer were found in the literature. Diffuse reflectance spectra between 490 and 620 nm were generated using Monte Carlo simulations for a wide range of melanosome volume fraction, epidermal thickness, blood volume, and oxygen saturation. Then, an inverse method was developed to retrieve these physiologically meaningful parameters from the simulated diffuse reflectance spectra of skin. A previously developed accurate and efficient semiempirical model for diffuse reflectance of two layered media was used instead of time-consuming Monte Carlo simulations. All parameters could be estimated with relative root-mean-squared error of less than 5percent for (i) melanosome volume fraction ranging from 1percent to 8percent, (ii) epidermal thickness from 20 to 150(mu)m, (iii) oxygen saturation from 25percent to 100percent, (iv) blood volume from 1.2percent to 10percent, and (v) tissue scattering coefficient typical of human skin in the visible part of the spectrum. A similar approach could be extended to other two-layer absorbing and scattering systems.
机译：我们提出了一种从漫反射光谱确定发色团浓度，血液饱和度和人皮肤表皮厚度的方法。人体皮肤近似为可变厚度的平面平行平板，由分别对应于表皮和真皮的半无限层支撑。将吸收系数建模为表皮中黑色素含量和真皮中血液含量和氧饱和度的函数。在文献中发现了各层的散射系数和折射率。使用蒙特卡洛模拟法，可在广泛的黑素体体积分数，表皮厚度，血容量和氧饱和度范围内产生490至620 nm的漫反射光谱。然后，开发了一种逆方法从皮肤的模拟漫反射光谱中检索这些生理上有意义的参数。使用先前开发的用于两层介质的漫反射率的准确而有效的半经验模型，而不是费时的蒙特卡洛模拟。对于（i）黑色素体体积分数范围从1％到8％，（ii）表皮厚度从20到150μm，（iii）血氧饱和度，估计所有参数的相对均方根误差均小于5％。 25％到100％，（iv）血液量从1.2％到10％，以及（v）在可见光谱范围内典型的人类皮肤组织散射系数。类似的方法可以扩展到其他两层吸收和散射系统。

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