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首页> 外文期刊>Applied optics >Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study
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Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study

机译：结合光学分辨率光声显微镜和光学相干断层扫描的微型探针，用于体内微循环研究

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摘要

Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue. Here we present a combined optical-resolution PAM (ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection. The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT.
机译：光声显微镜（PAM）对光吸收敏感，而光学相干断层扫描（OCT）基于光学反向散射。将PAM和OCT结合使用可以提供有关生物组织的补充信息。在这里，我们介绍光学分辨率PAM（ORPAM）和OCT的组合系统，该系统通过总直径为2.3 mm的微型探针集成，适合在微创手术或内窥镜检查过程中通过标准内窥镜或腹腔镜端口插入。混合探头由用于OCT（光传输/检测）和ORPAM（光激发）的公共光路以及用于光声检测的10 MHz非聚焦超声换能器组成。组合系统对ORPAM和OCT的横向分辨率均为15μm。

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