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首页> 外文期刊>Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry >Inhibitory Activities of Griseofulvin and Its Analogues against Phytopathogenic Fungi
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Inhibitory Activities of Griseofulvin and Its Analogues against Phytopathogenic Fungi

机译：灰黄霉素及其类似物对植物病原真菌的抑制作用

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The antifungal activity of griseofulvin was evaluated against phytopathogenic fungi including Fusarium moniliforme, Fusarium solani, Fusarium oxysporum and Colletotrichum truncatum. The greenhouse test was also made to evaluate the control efficiency of griseofulvin to eggplant powdery mildew. The results indicated griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test. Subsequently, five griseofulvin analogues were synthesized and evaluated for antifungal activities against the four fungi. The results showed that these compounds performed significantly different activities in comparison with griseofulvin. The inhibition mechanism and bioavailability of active analogues were taken to expound their different performance and relations of structure and activity. The solubility in different solvents of analogues and griseofulvin was roughly evaluated and compared.
机译：灰黄霉素的抗真菌活性被评估为对植物致病性真菌的影响，包括枯萎病镰刀菌，茄枯萎病菌，尖孢镰刀菌和截骨炭疽菌。还进行了温室试验以评价灰黄霉素对茄子白粉病的防治效果。结果表明灰黄霉素不仅可以在实验室实验中明显抑制真菌，而且在温室试验中可以有效控制茄子白粉病。随后，合成了五个灰黄霉素的类似物，并评估了对四种真菌的抗真菌活性。结果表明，与灰黄霉素相比，这些化合物具有明显不同的活性。研究了活性类似物的抑制机理和生物利用度，阐明了它们的不同性能以及结构与活性之间的关系。粗略评估和比较了类似物和灰黄霉素在不同溶剂中的溶解度。

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