...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Cardiology >Prognostic performance of kinetic changes of high-sensitivity troponin T in acute coronary syndrome and in patients with increased troponin without acute coronary syndrome
【24h】

Prognostic performance of kinetic changes of high-sensitivity troponin T in acute coronary syndrome and in patients with increased troponin without acute coronary syndrome

机译：高敏肌钙蛋白T动力学改变在急性冠状动脉综合征和无急性冠脉综合征的肌钙蛋白升高患者的预后表现

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background We sought to evaluate the prognostic impact of absolute and relative kinetic changes of high-sensitivity cardiac Troponin T (hs-cTnT) in comparison to baseline hs-cTnT elevations for risk stratification in acute coronary syndrome (ACS) and non-ACS conditions with increased hs-cTnT. Methods hs-cTnT was measured serially in patients presenting with acute symptoms to our emergency department. We assessed the prognostic performance of baseline and serial hs-cTnT concentrations in all consecutive patients with ACS (n = 406) or hs-cTnT increases not due to ACS (n = 442) within 3-6 h after admission. Results Mortality rates were higher, albeit not statistically, in non-ACS (53/442 = 12.0%) than ACS patients (36/406 = 8.9%). In ACS patients, receiver operating characteristics (ROC) revealed optimized cut-off values of 12.2 ng/L for absolute δ-change (AUC = 0.66, p < 0.001), 31.2 ng/L for baseline hs-cTnT (AUC = 0.71, p < 0.001) and 45.2 ng/L for maximal hs-cTnT (AUC = 0.68, p < 0.001). C-statistics showed superiority of absolute δ-changes (p = 0.0003), baseline hs-cTnT (p = 0.04) and maximal hs-cTnT (p = 0.02) compared to relative δ-changes. However, the combination of baseline hs-cTnT values with either absolute or relative δ-changes did not improve risk prediction compared to baseline hs-cTnT alone (p = n.s.). In non-ACS conditions, the ROC-optimized cut-off value of 46.2 ng/L for baseline hs-cTnT (AUC = 0.661, p < 0.001) was superior to absolute (p = 0.007) and relative δ-changes regarding prognostication (p = 0.045). Conclusions Our data suggest that the magnitude of baseline hs-cTnT, and not acute dynamic changes, convey superior long-term prognostic information in ACS and non-ACS conditions. Moreover, absolute and relative kinetic δ-changes of hs-cTnT do not add significant incremental value in risk assessment in both conditions.
机译：背景我们试图评估高敏性心肌肌钙蛋白T（hs-cTnT）的绝对和相对动力学变化与基线hs-cTnT升高相比对急性冠脉综合征（ACS）和非ACS患者的危险分层的预后影响hs-cTnT增加。方法对我院急诊科急性症状患者进行连续hs-cTnT测定。我们评估了入院后3-6小时内所有连续的ACS（n = 406）或hs-cTnT升高不是由于ACS（n = 442）的患者的基线和连续hs-cTnT浓度的预后表现。结果非ACS患者（53/442 = 12.0％）的死亡率高于ACS患者（36/406 = 8.9％）（尽管没有统计）。在ACS患者中，接收器的工作特性（ROC）显示，绝对δ变化的最佳临界值为12.2 ng / L（AUC = 0.66，p <0.001），基线hs-cTnT为31.2 ng / L（AUC = 0.71， p <0.001）和最大hs-cTnT的45.2 ng / L（AUC = 0.68，p <0.001）。 C统计量显示相对于相对δ变化，绝对δ变化（p = 0.0003），基线hs-cTnT（p = 0.04）和最大hs-cTnT（p = 0.02）优越。但是，与单独的基线hs-cTnT相比，基线hs-cTnT值与绝对或相对δ变化的组合并不能提高风险预测（p = n.s.）。在非ACS条件下，基线hs-cTnT的ROC优化临界值46.2 ng / L（AUC = 0.661，p <0.001）优于绝对值（p = 0.007）和相对于预后的δ变化（ p = 0.045）。结论我们的数据表明，基线hs-cTnT的幅度（而非急性动态变化）可在ACS和非ACS情况下传达优越的长期预后信息。而且，在两种情况下，hs-cTnT的绝对和相对动力学δ变化都不会在风险评估中增加明显的增量值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号