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首页> 外文期刊>Critical care : >Coagulation in sepsis: all bugs bite equally.
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Coagulation in sepsis: all bugs bite equally.

机译：脓毒症中的凝结：所有臭虫均被叮咬。

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摘要

Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder.
机译：败血症几乎总是导致止血异常，从实验室的微小变化到严重的弥散性血管内凝血。来自临床和实验研究的令人信服的证据表明，弥散性血管内凝血与微血管功能障碍的发病机制有关，并导致器官衰竭。来自针对严重脓毒症患者的重组活化蛋白C的PROWESS III期临床试验的数据证实了这一观点，并证明绝大多数患有严重脓毒症的患者具有全身性凝血激活标记物增加，生理性抗凝蛋白减少和纤维蛋白溶解降低。引起感染的微生物类型与凝血功能障碍的存在或严重程度之间没有关联。

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