...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Pharmacology: An International Journal >Desloratadine citrate disodium injection, a potent histamine H-1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades
【24h】

Desloratadine citrate disodium injection, a potent histamine H-1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades

机译：柠檬酸去氯雷他定二钠注射液，一种有效的组胺H-1受体拮抗剂，通过抑制ERK1 / 2和NF-κB信号级联反应，抑制卵清蛋白诱导的过敏性鼻炎豚鼠模型和组胺诱导的人鼻上皮细胞的趋化因子生成。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemokines have chemotactic properties on leukocyte subsets whose modulation plays a pivotal role in allergic inflammatory processes. Our present study was designed to investigate the anti-allergic and anti-inflammatory properties of desloratadine citrate disodium injection (DLC) and elucidate the molecular mechanisms of its anti-inflammatory properties. The anti-allergic effects of DLC were evaluated based on allergic symptoms, serological marker production and histological changes of the nasal mucosa in guinea pigs model of allergic rhinitis. The anti-inflammatory properties and molecular mechanisms of DLC were explored by studying the regulation of a set of chemokines and extracellular signal-regulated kinase (ERK)1/2 and nuclear factor-kappa B (NF-kappa B) pathways, after DLC treatment in guinea pigs model of allergic rhinitis in vivo and histamine-activated human nasal epithelial cells (HNECs) in vitro. In vivo model in guinea pigs, DLC alleviated the rhinitis symptoms, inhibited inflammatory cells infiltration in nasal lavage fluid (NLF) and histamine, monocyte chemotactic protein (MCP)-1, regulated on activation normal T cell expressed, and presumably secreted (RANTEs) and interleukin (IL)-8 release in sera and P-ERK1/2 and NF-kappa B activation in nasal mucosa. In vitro, DLC markedly inhibited histamine-induced production of MCP-1, RANTEs and IL-8 and suppressed c-Raf, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and ERK1/2 activation in HNECs. These results provide evidence that DLC possesses potent anti-allergic and anti-inflammatory properties. The mechanism of action underlying DLC in allergic inflammation appears to be inhibition of the phosphorylation of ERK1/2, in addition to blocking of the NF-kappa B pathway. (C) 2015 Elsevier B.V. All rights reserved.
机译：趋化因子对白细胞亚群具有趋化特性，其调节作用在变应性炎症过程中起关键作用。本研究旨在研究柠檬酸去氯雷他定二钠注射液（DLC）的抗过敏和抗炎特性，并阐明其抗炎特性的分子机理。根据变应性鼻炎豚鼠模型的变态反应症状，血清学标志物产生和鼻黏膜组织学变化，评估了DLC的抗变态反应作用。通过研究DLC处理后一组趋化因子和细胞外信号调节激酶（ERK）1/2和核因子-κB（NF-κB）途径的调控，探讨了DLC的抗炎特性和分子机制。豚鼠体内的过敏性鼻炎模型和体外组胺激活的人鼻上皮细胞（HNEC）模型。在豚鼠体内模型中，DLC减轻了鼻炎症状，抑制了鼻灌洗液（NLF）和组胺中炎性细胞的浸润，单核细胞趋化蛋白（MCP）-1，调节了正常T细胞的表达并推测其分泌（RANTE）。血清中白介素（IL）-8释放，鼻粘膜中P-ERK1 / 2和NF-κB活化。在体外，DLC显着抑制组胺诱导的MCP-1，RANTE和IL-8的产生，并抑制HNEC中的c-Raf，丝裂原激活的蛋白/细胞外信号调节激酶激酶（MEK）和ERK1 / 2激活。这些结果提供了DLC具有有效的抗过敏和抗炎特性的证据。 DLC在过敏性炎症中的作用机制似乎是对ERK1 / 2的磷酸化的抑制，以及对NF-κB通路的阻断。 （C）2015 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号