...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Pharmacology: An International Journal >Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat
【24h】

Effect of combination therapy consisting of enalapril, alpha-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat

机译：依那普利，α-硫辛酸和薄荷油联合治疗对高脂/低剂量链脲佐菌素治疗的大鼠糖尿病神经病变的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have previously demonstrated that treating diabetic rats with enalapril, an angiotensin converting enzyme (ACE) inhibitor, alpha-lipoic acid, an antioxidant, or menhaden oil, a natural source of omega-3 fatty acids can partially improve diabetic peripheral neuropathy. In this study we sought to determine the efficacy of combining these three treatments on vascular and neural complications in a high fat fed low dose streptozotocin treated rat, a model of type 2 diabetes. Rats were fed a high fat diet for 8 weeks followed by a 30 mg/kg dose of streptozotocin. Eight weeks after the onset of hyperglycemia diabetic rats were treated with a combination of enalapril, cc-lipoic acid and menhaden oil. Diabetic rats not receiving treatment were continued on the high fat diet. Glucose clearance was impaired in diabetic rats and significantly improved with treatment. Diabetes caused steatosis, elevated serum lipid levels, slowing of motor and sensory nerve conduction, thermal hypoalgesia, reduction in intraepidermal nerve fiber profiles, decrease in cornea sub-basal nerve fiber length and corneal sensitivity and impairment in vascular relaxation to acetylcholine and calcitonin gene-related peptide in epineurial arterioles of the sciatic nerve. Treating diabetic rats with the combination of enalapril, alpha-lipoic acid and menhaden oil reversed all these deficits to near control levels except for motor nerve conduction velocity which was also significantly improved compared to diabetic rats but remained significantly decreased compared to control rats. These studies suggest that a combination therapeutic approach may be most effective for treating vascular and neural complications of type 2 diabetes. Published by Elsevier B.V.
机译：我们先前已经证明，使用依那普利，血管紧张素转换酶（ACE）抑制剂，α-硫辛酸，抗氧化剂或薄荷油（一种天然的omega-3脂肪酸来源）治疗糖尿病大鼠可以部分改善糖尿病周围神经病变。在本研究中，我们试图确定在高脂饮食，低剂量链脲佐菌素治疗的大鼠（一种2型糖尿病模型）中，将这三种治疗方法联合使用对血管和神经并发症的功效。给大鼠喂高脂饮食8周，然后给予30 mg / kg剂量的链脲佐菌素。高血糖发作后八周，糖尿病大鼠用依那普利，α-硫辛酸和薄荷油联合治疗。未接受治疗的糖尿病大鼠继续接受高脂饮食。糖尿病大鼠的葡萄糖清除率受损，并通过治疗显着改善。糖尿病导致脂肪变性，血脂水平升高，运动和感觉神经传导减慢，热痛觉过敏，表皮内神经纤维分布减少，角膜下基底神经纤维长度和角膜敏感性降低以及对乙酰胆碱和降钙素基因的血管舒张功能受损-坐骨神经海马小动脉中的相关肽。用依那普利，α-硫辛酸和薄荷油的组合治疗糖尿病大鼠可将所有这些缺陷逆转至接近对照水平，但运动神经传导速度相比糖尿病大鼠也明显改善，但与对照大鼠相比仍然明显降低。这些研究表明，联合治疗方法可能对治疗2型糖尿病的血管和神经并发症最有效。由Elsevier B.V.发布

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号