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首页> 外文期刊>Contemporary clinical trials >Why is recruitment to trials difficult? An investigation into recruitment difficulties in an RCT of supported employment in patients with severe mental illness.
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Why is recruitment to trials difficult? An investigation into recruitment difficulties in an RCT of supported employment in patients with severe mental illness.

机译：为什么招募参加审判很困难？对严重精神疾病患者支持性就业的RCT中招募困难的调查。

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BACKGROUND: Under-recruitment to randomised controlled trials (RCTs) is often problematic and there may be particular difficulties in recruiting patients with severe mental illness. AIM: To evaluate reasons for under-recruitment in an RCT of patients with severe mental illness METHODS: Qualitative study during the recruitment phase of an RCT of supported employment. Trial staff and recruiting clinicians were interviewed. Data were analyzed thematically using constant comparative techniques. RESULTS: Recruitment rates were low. Five main reasons for recruitment difficulties were found. These included: (i) misconceptions about trials, (ii) lack of equipoise, (iii) misunderstanding of the trial arms, (iv) variable interpretations of eligibility criteria, (v) paternalism. CONCLUSION: Reasons for recruitment difficulties in trials involving patients with severe mental illness include issues that occur in trials in general, but others are more specific to these patients. Clinician and patient involvement in the study design may improve recruitment in future similar trials.
机译：背景：招募随机对照试验（RCT）经常会出现问题，招募患有严重精神疾病的患者可能会有特别的困难。目的：评估患有严重精神疾病的患者接受随机对照试验（RCT）人数不足的原因方法：在支持性就业的随机对照试验（RCT）的招募阶段进行定性研究。采访了审判人员和招募临床医生。使用恒定的比较技术对数据进行主题分析。结果：招聘率低。发现了招募困难的五个主要原因。其中包括：（i）对审判的误解，（ii）缺乏平衡，（iii）对审判部门的误解，（iv）资格标准的各种解释，（v）家长式作风。结论：在涉及重度精神疾病患者的试验中，招募困难的原因包括一般试验中出现的问题，但其他原因更具体于这些患者。临床医生和患者参与研究设计可能会改善以后的类似试验的招募。

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