Apoptosis of endothelial cells in bacterial sepsis and severe Plasmodium falciparum malaria: Do we know enough to consider clinical trials?

Fawaz Mzayek; Joni Ylostalo; Donald J. Krogstad

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Apoptosis of endothelial cells in bacterial sepsis and severe Plasmodium falciparum malaria: Do we know enough to consider clinical trials?

机译：细菌性脓毒症和严重恶性疟原虫疟疾中内皮细胞的凋亡：我们是否知道足够多的信息以考虑进行临床试验？

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For the reasons listed above, we suggest cautious optimism about the likelihood of success for innovative antiapoptotic strategies for bacterial sepsis, and more caution than optimism at this time about the feasibility of antiapoptotic strategies for severe P. falciparum malaria.

机译：由于上述原因，我们建议对细菌性败血症的创新抗凋亡策略成功的可能性持谨慎乐观的态度，而在此时，对于严重恶性疟原虫疟疾的抗凋亡策略的可行性，比乐观的态度要谨慎。

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《Critical care medicine》 |2008年第9期|共3页
作者
Fawaz Mzayek; Joni Ylostalo; Donald J. Krogstad;
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正文语种 eng
中图分类护理学;
关键词
malaria; Plasmodium falciparum; apoptosis; endothelial cells; bacterial sepsis; 疟原虫; 恶性;

机译：malaria;Plasmodium falciparum;apoptosis;endothelial cells;bacterial sepsis;疟原虫;恶性;

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专利

1. Apoptosis of endothelial cells in bacterial sepsis and severe Plasmodium falciparum malaria: Do we know enough to consider clinical trials? [J] . Fawaz Mzayek, Joni Ylostalo, Donald J. Krogstad Critical care medicine . 2008,第9期

机译：细菌性脓毒症和严重恶性疟原虫疟疾中内皮细胞的凋亡：我们是否知道足够多的信息以考虑进行临床试验？
2. Plasmodium falciparum Malaria: Reduction of Endothelial Cell Apoptosis In Vitro [J] . Christoph Josef Hemmer, Hans Anton Lehr, Kathi Westphal, Infection and immunity . 2005,第3期

机译：恶性疟原虫疟疾：减少内皮细胞凋亡的体外。
3. Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines [J] . Danielle I Stanisic, Xue Q Liu, Sai Lata De, Malaria Journal . 2015,第S1期

机译：开发培养的恶性疟原虫血期疟疾细胞库，用于抗疟疾药物和疫苗的体内早期临床试验评估
4. Just-in-time expression of influential genes in the cellular networks of the malaria parasite Plasmodium falciparum during the red blood cycle [C] . Xinran Yu, Hao Zhang, Timothy G. Lilburn, IEEE International Conference on Bioinformatics and Biomedicine . 2016

机译：疟疾寄生虫恶性疟原虫红细胞周期内细胞网络中影响基因的及时表达
5. Development of a Viral Vaccine Vector Expressing a Plasmodium falciparum Erythrocyte Membrane Protein Domain to Target Severe Malaria [D] . Crager, Sara Eve 2011

机译：表达表达疟原虫红细胞膜蛋白结构膜蛋白域的病毒疫苗载体以靶向严重疟疾
6. Inhibition of Plasmodium falciparum Field Isolates-Mediated Endothelial Cell Apoptosis by Fasudil: Therapeutic Implications for Severe Malaria [O] . Estelle S. Zang-Edou, Ulrick Bisvigou, Zacharie Taoufiq, 2010

机译：法舒地尔对恶性疟原虫野外分离株介导的内皮细胞凋亡的抑制作用：严重疟疾的治疗意义
7. Inhibition of Plasmodium falciparum Field Isolates-Mediated Endothelial Cell Apoptosis by Fasudil: Therapeutic Implications for Severe Malaria [O] . Zang-Edou, Estelle S., Bisvigou, Ulrick, Taoufiq, Zacharie, 2010

机译：法舒地尔抑制恶性疟原虫田间分离株介导的内皮细胞凋亡：对严重疟疾的治疗意义
8. HLA-A2 Supertype-Restricted Cell-Mediated Immunity by Peripheral Blood Mononuclear Cells Derived from Malian Children with Severe or Uncomplicated Plasmodium falciparum Malaria and Healthy Controls [R] . Lyke, K. E. , Burges, R. B. , Cissoko, Y. , 2005

机译：HLa-a2超类型限制细胞介导的免疫由外周血单核细胞来源于马里儿童严重或不复杂的恶性疟原虫疟疾和健康对照

Apoptosis of endothelial cells in bacterial sepsis and severe Plasmodium falciparum malaria: Do we know enough to consider clinical trials?

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