Microvascular dysfunction as a cause of organ dysfunction in severe sepsis.

Vincent JL; De Backer D

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Microvascular dysfunction as a cause of organ dysfunction in severe sepsis.

机译：微血管功能障碍是严重败血症中器官功能障碍的原因。

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Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction remain unclear, but there are considerable experimental data showing reduced microcirculatory flow, particularly of small vessels, and increased heterogeneity. With the development of newer imaging techniques, human studies have also been conducted and have given rise to similar findings. Importantly, the degree of microvascular disturbance and its persistence is associated with poorer outcomes. The ability to influence these changes may result in better outcomes and bedside systems, enabling direct visualization of the microcirculation, which will help in the assessment of ongoing microcirculatory dysfunction and its response to established and new therapeutic interventions.

机译：减少的微血管灌注与严重的败血症相关的器官功能障碍和多器官功能衰竭有关。微血管功能障碍的确切机制尚不清楚，但是有大量实验数据显示微循环流量减少，尤其是小血管的微循环流量减少，异质性增加。随着更新的成像技术的发展，已经进行了人类研究，并且产生了类似的发现。重要的是，微血管紊乱的程度及其持续性与较差的预后相关。影响这些变化的能力可能会导致更好的预后和床旁系统，从而可以直接可视化微循环，这将有助于评估正在进行的微循环功能障碍及其对既定和新治疗干预措施的反应。

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《Critical care :》 |2005年第4期|共4页
作者
Vincent JL; De Backer D;
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正文语种 eng
中图分类临床医学;
关键词
Microcirculation; Sepsis; 微循环; 脓毒症;

机译：Microcirculation;Sepsis;微循环;脓毒症;

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专利

1. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. [J] . Vincent JL, De Backer D Critical care : . 2005,第Suppla4期

机译：微血管功能障碍是严重败血症中器官功能障碍的原因。
2. Endothelial nitric oxide synthase 894G-->T but not -786T-->C gene polymorphism is associated with organ dysfunction and increased mortality in patients with severe sepsis. [J] . Ma P, Zhu Y, Qiu H, The Journal of trauma . 2011,第4期

机译：严重败血症患者的内皮一氧化氮合酶894G-> T但不是-786T-> C基因多态性与器官功能障碍和死亡率增加有关。
3. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis. [J] . Mayr FB, Yende S, Linde Zwirble WT, JAMA: the Journal of the American Medical Association . 2010,第24期

机译：感染率和急性器官功能障碍风险可作为严重败血症种族差异的解释。
4. Cardiac Autonomic Dysfunction in Cardiogenic and Non-Cardiogenic-Triggered Multiple Organ Dysfunction Syndrome (MODS) and the Use of beta-Blockers [C] . R. Hennen, I. Friedrich, D. Hoyer, Conference on Shock . 2008

机译：心肌和非心绞源触发的多器官功能障碍综合征（MODS）的心脏自主功能障碍以及使用β-ocketers
5. Targeting Platelets in Multiple Organ Dysfunction Syndrome in Sepsis. [D] . Hoptay, Claire Elise. 2016

机译：针对败血症中的多器官功能不全综合征的血小板。
6. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis [O] . Jean-Louis Vincent, Daniel De Backer 2005

机译：微血管功能障碍是严重脓毒症器官功能障碍的原因
7. Microvascular dysfunction as a cause of organ dysfunction in severe sepsis [O] . Vincent, Jean Louis, De Backer, Daniel 2005

机译：微血管功能障碍是严重脓毒症器官功能障碍的原因

Microvascular dysfunction as a cause of organ dysfunction in severe sepsis.

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