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Age of blood: does it make a difference?

机译：血统时代：有什么不同吗？

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摘要

During the past 20 years, the perceived value of blood transfusions has changed as it has become appreciated that transfusions are not without risk. Red blood cell transfusion has been associated with disease transmission and immunosuppression for some time. More recently, proinflammatory consequences of red blood cell transfusion have also been documented. Moreover, it has become increasingly evident that stored red blood cells undergo time-dependent metabolic, biochemical, and molecular changes. This 'storage lesion' may be responsible for many of the adverse effects of red blood cell transfusion. Clinically, the age of blood has been associated with multiple organ failure, postoperative pneumonia, and wound infection. The relationship between age of blood and clinical adverse effects needs further study.
机译：在过去的20年中，人们逐渐意识到输血并非没有风险，因此人们对输血的认知价值发生了变化。红细胞输注与疾病传播和免疫抑制有关已有一段时间。最近，还记录了红细胞输血的促炎作用。此外，越来越明显的是，储存的红细胞会经历时间依赖性的代谢，生化和分子变化。这种“存储病变”可能是造成红细胞输血的许多不良反应的原因。临床上，血液年龄与多器官功能衰竭，术后肺炎和伤口感染有关。血龄与临床不良反应之间的关系需要进一步研究。

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